{"id":67329,"date":"2008-09-10T00:00:00","date_gmt":"2008-09-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/streptococcus-neumoniae-resistente-a-amoxicilina-comportamiento-ecologico-en-un-modelo-farmacodinamicoin-vitro\/"},"modified":"2008-09-10T00:00:00","modified_gmt":"2008-09-10T00:00:00","slug":"streptococcus-neumoniae-resistente-a-amoxicilina-comportamiento-ecologico-en-un-modelo-farmacodinamicoin-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/streptococcus-neumoniae-resistente-a-amoxicilina-comportamiento-ecologico-en-un-modelo-farmacodinamicoin-vitro\/","title":{"rendered":"Streptococcus neumoniae resistente a amoxicilina: comportamiento ecol\u00f3gico en un modelo farmacodin\u00e1mico\u00bbin vitro\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fabio Cafini Barrado <\/strong><\/h2>\n<p>Null streptococcus pneumoniae es un frecuente colonizador de la nasofaringe y es causante de otitis, neumon\u00eda, septicemia y meningitis en el ser humano, siendo \u00e9ste el \u00fanico hospedador conocido. Este microorganismo ha conseguido desarrollar resistencia fr ente a varios tipos de antimicrobianos, entre los que destacan, por su habitual uso en la cl\u00ednica, los betalact\u00e1micos, macr\u00f3lidos y quinolonas. La resistencia a betalact\u00e1micos en este microorganismo ha surgido desde la utilizaci\u00f3n en cl\u00ednica de la pe nicilina, comprometiendo adem\u00e1s la sensibilidad de los aislados a otros antimicrobianos de la misma familia, como cefalosporinas y aminopenicilinas. El principal mecanismo por el cual s. Pneumoniae reduce su sensibilidad frente a los betalact\u00e1micos e s la alteraci\u00f3n de las prote\u00ednas fijadoras de penicilina (pbps). Las pbps est\u00e1n implicadas en la formaci\u00f3n de la pared bacteriana, y la uni\u00f3n a betalact\u00e1micos implica su inactivaci\u00f3n y el bloque de dicho paso en la s\u00edntesis del peptidoglicano. Adem\u00e1s  de las pbps, otros genes como murm participan de forma indirecta en el desarrollo de resistencias. En el presente trabajo, adem\u00e1s de caracterizar gen\u00e9ticamente aislados hospitalarios con alta resistencia a amoxicilina, se ha investigado la posible c arga ecol\u00f3gica, medida en funci\u00f3n de la capacidad de crecimiento, de este tipo de mecanismos de resistencia. Mediante un sistema farmacodin\u00e1mico in vitro, donde se simulan las concentraciones de antimicrobiano alcanzadas en el organismo (teniendo en cuenta factores como la concentraci\u00f3n m\u00e1xima, la distribuci\u00f3n y la eliminaci\u00f3n), se ha evaluado la ecolog\u00eda de un cultivo mixto de varias cepas de s. Pneumoniae en ausencia y en presencia de 5 antimicrobianos utilizados frecuentemente en el tratamien to de este pat\u00f3geno. Gracias al estudio de la evoluci\u00f3n de un in\u00f3culo mixto bajo tratamiento, hemos podido observar la importancia de la ecolog\u00eda y la interacci\u00f3n de los distintos pat\u00f3genos en la aparici\u00f3n de resistencias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Streptococcus neumoniae resistente a amoxicilina: comportamiento ecol\u00f3gico en un modelo farmacodin\u00e1mico\u00bbin vitro\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Streptococcus neumoniae resistente a amoxicilina: comportamiento ecol\u00f3gico en un modelo farmacodin\u00e1mico\u00bbin vitro\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fabio Cafini Barrado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Alou Cervera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fabio Cafini Barrado Null streptococcus pneumoniae es un frecuente colonizador de la nasofaringe y es causante de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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