{"id":67474,"date":"2018-03-09T22:55:55","date_gmt":"2018-03-09T22:55:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/respuesta-inflamatoria-esplacnica-en-la-colestasis-microquirurgica-experimental\/"},"modified":"2018-03-09T22:55:55","modified_gmt":"2018-03-09T22:55:55","slug":"respuesta-inflamatoria-esplacnica-en-la-colestasis-microquirurgica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/respuesta-inflamatoria-esplacnica-en-la-colestasis-microquirurgica-experimental\/","title":{"rendered":"Respuesta inflamatoria espl\u00e1cnica en la colestasis microquir\u00fargica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Garcia Dominguez <\/strong><\/h2>\n<p>Null introducci\u00f3n  la colestasis es un s\u00edndrome cl\u00ednico que se manifiesta por la retenci\u00f3n hep\u00e1tica de productos que se excretan normalmente en la bilis, en particular sales biliares. A medida que \u00e9ste proceso progresa en el tiempo pueden aparecer icteric ia e hipercolesterolemia y finalmente cursa  con fibrosis, cirrosis y signos cl\u00ednicos de fallo hep\u00e1tico. la causa m\u00e1s frecuente de colestasis extrahep\u00e1tica en la cl\u00ednica humana es la obstrucci\u00f3n mec\u00e1nica de la v\u00eda biliar extrahep\u00e1tica, que puede ser secundaria a malformaciones de la v\u00eda biliar y pancre\u00e1ticas, litiasis biliar, infecciones y tumores.  la colestasis extrahep\u00e1tica en la rata cursa con alteraciones espl\u00e1cnicas y sist\u00e9micas en cuya producci\u00f3n podr\u00edan estar implicados mecanismos patog\u00e9 nicos de naturaleza inflamatoria, por lo que un modelo experimental de colestasis extrahep\u00e1tica microquir\u00fargica podr\u00eda ser \u00fatil a la hora de caracterizar el tipo de respuesta inflamatoria espl\u00e1cnica secundaria a la colestasis obstructiva.  metodos    se utilizaron  85 ratas sprague-dawley macho que fueron divididas en 2 grupos: uno al que se le realiz\u00f3 la t\u00e9cnica de colestasis microquir\u00fargica extrahep\u00e1tica ( n= 53) y otro al que se le realiz\u00f3 la t\u00e9cnica de pseudo-operaci\u00f3n (n=32).  Con el f\u00edn de reducir la mortalidad a los animales  se les administr\u00f3 una dosis semanal de vitamina k1  durante las 6 semanas del estudio. Pasado \u00e9ste tiempo sobrevivieron 44 animales con colestasis y 32 pseudo-operados, todos fueron sacrificados . Se evaluaron lo s cambios en los pesos: corporal, hep\u00e1tico, renal,espl\u00e9nico y testicular; el  desarrollo de circulaci\u00f3n colateral venosa portosist\u00e9mica;  el grado de vasculopat\u00eda venosa mesent\u00e9rica,  las alteraciones histol\u00f3gicas hep\u00e1ticas, los valores de los par\u00e1me tros bioqu\u00edmicos propios de lesi\u00f3n hepatobiliar, los niveles de prote\u00ednas de fase aguda (prote\u00edna mayor \u00e1cida ?1 y ?1-glicoprote\u00edna \u00e1cida); y los niveles en los tejidos espl\u00e1cnicos de citoquinas proinflamatorias (tnf-? , Il-1?) Y antiinflamatorias (i l-4 , il-10). Tambi\u00e9n  se cuantific\u00f3 la concentraci\u00f3n en \u00edleon y ganglios linf\u00e1ticos mesent\u00e9ricos de una proteasa espec\u00edfica de las c\u00e9lulas cebadas de las mucosas de la rata (rmcp-ii).  resultados  los animales con colestasis microquir\u00fargica extrahep \u00e1tica presentaban signos  caracter\u00edsticos del s\u00edndrome colest\u00e1sico : ictericia y coluria intensas, as\u00ed como acolia moderada y hepatoesplenomegalia. Respecto a los  pseudo-operados  ten\u00edan menor incremento de peso corporal , aumento  de la relaci\u00f3n pe<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Respuesta inflamatoria espl\u00e1cnica en la colestasis microquir\u00fargica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Respuesta inflamatoria espl\u00e1cnica en la colestasis microquir\u00fargica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Garcia Dominguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Angeles Alller Reyero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda paz (secretario) Nava hidalgo <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Garcia Dominguez Null introducci\u00f3n la colestasis es un s\u00edndrome cl\u00ednico que se manifiesta por la retenci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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