{"id":67584,"date":"2018-03-09T22:56:03","date_gmt":"2018-03-09T22:56:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fosfacenos-en-sa%c2%adntesis-heteroca%c2%adclica-preparacion-de-piridinotienopirimidinas-y-ligandos-polidentados-relacionados-mediante-procesos-tandem-domino\/"},"modified":"2018-03-09T22:56:03","modified_gmt":"2018-03-09T22:56:03","slug":"fosfacenos-en-sa%c2%adntesis-heteroca%c2%adclica-preparacion-de-piridinotienopirimidinas-y-ligandos-polidentados-relacionados-mediante-procesos-tandem-domino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/fosfacenos-en-sa%c2%adntesis-heteroca%c2%adclica-preparacion-de-piridinotienopirimidinas-y-ligandos-polidentados-relacionados-mediante-procesos-tandem-domino\/","title":{"rendered":"Fosfacenos en s\u00edntesis heteroc\u00edclica. preparaci\u00f3n de piridinotienopirimidinas y ligandos polidentados relacionados mediante procesos t\u00e1ndem-domin\u00f3"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gerardo David Blanco Diaz <\/strong><\/h2>\n<p>Se ha desarrollado una metodolog\u00eda, muy simple y eficaz, para la s\u00edntesis de pirazinotienopirimidinas mediante procesos domin\u00f3 aza-witting\/adici\u00f3n nucle\u00f3fila intermolecular\/ciclaci\u00f3n intramolecular. Se han investigado el efecto de los nucle\u00f3filos y de los heterocumulenos empleados en la regioselectividad de la reacci\u00f3n. Esta metodolog\u00eda se ha mostrado muy eficaz para la preparaci\u00f3n de bi (pirazinotienopirimidinas), compuestos que no son facilmetnte accesibles por otros procedimientos sint\u00e9ticos. se ha estudiado la s\u00edntesis en una sola etapa de pirazinotienopirimidinas, mediante reacciones t\u00e1ndem aza-wittig\/electrociclaci\u00f3n. pirazinotienopirimidinas c\u00edclicas, una clase de compuestos particularmente dificiles de obteneer, se han podido preparar adecuadamente mediante reacciones t\u00e1ndem aza-wittig intramolecular\/heterociclaci\u00f3n. Se ha comprobado que esta metodolog\u00eda es apropiada para la preparaci\u00f3n de otro tipo de sistemas como pirazinotienotriazolopirimidinas y bis(pirazinotienotriazolopirimidinas). esta estrategia, que implica reacciones domin\u00f3 en una sola operaci\u00f3n sint\u00e9tica, es econ\u00f3mica y medioambientalmente muy ventajosa por la sencillez del procedimiento, reducci\u00f3n de las etapas de purificaci\u00f3n y aislamiento, y minimizaci\u00f3n del tiempo, costes y producci\u00f3n de residuos. el sistema de pirazinotienopirimidina es is\u00f3stero de la 1,10-fenantrolina y podr\u00eda ser de inter\u00e9s, por consiguiente, para preparar nuevos ligandos polidentados capaces de autoacoplarse y dar estructuras supramoleculares. Su posible utilidad para la obtenci\u00f3n de compuestos con diferente actividad farmacol\u00f3gica parece tambien evidente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fosfacenos en s\u00edntesis heteroc\u00edclica. preparaci\u00f3n de piridinotienopirimidinas y ligandos polidentados relacionados mediante procesos t\u00e1ndem-domin\u00f3<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fosfacenos en s\u00edntesis heteroc\u00edclica. preparaci\u00f3n de piridinotienopirimidinas y ligandos polidentados relacionados mediante procesos t\u00e1ndem-domin\u00f3 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gerardo David Blanco Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Quintela L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 joaquin Barluenga mur <\/li>\n<li>Francisco Palacios gambra (vocal)<\/li>\n<li>pedro Molina buend\u00eda (vocal)<\/li>\n<li>susana Conde ceide (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gerardo David Blanco Diaz Se ha desarrollado una metodolog\u00eda, muy simple y eficaz, para la s\u00edntesis de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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