{"id":67657,"date":"2018-03-09T22:56:07","date_gmt":"2018-03-09T22:56:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/optimizacion-de-nuevos-sistemas-terapeuticos-basados-en-la-microencapsulacion-de-celulas-utilizando-la-eritropoyetina-como-farmaco-modelo\/"},"modified":"2018-03-09T22:56:07","modified_gmt":"2018-03-09T22:56:07","slug":"optimizacion-de-nuevos-sistemas-terapeuticos-basados-en-la-microencapsulacion-de-celulas-utilizando-la-eritropoyetina-como-farmaco-modelo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-de-farmacos\/optimizacion-de-nuevos-sistemas-terapeuticos-basados-en-la-microencapsulacion-de-celulas-utilizando-la-eritropoyetina-como-farmaco-modelo\/","title":{"rendered":"Optimizacion de nuevos sistemas terapeuticos basados en la microencapsulacion de celulas utilizando la eritropoyetina como farmaco modelo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz M\u00aa De Castro Matos <\/strong><\/h2>\n<p>La aplicaci\u00f3n a nivel cl\u00ednico de la microencapsulaci\u00f3n de c\u00e9lulas requiere la superaci\u00f3n de algunos escollos. Estas limitaciones implican tanto aspectos tecnol\u00f3gicos como biol\u00f3gicos. As\u00ed, entre los primeros es necesaria la b\u00fasqueda de alternativas al cl\u00e1sico policati\u00f3n poli-l-lisina (pll) para constituir un sistema de inmovilizaci\u00f3n mec\u00e1nicamente m\u00e1s estable, biocompatible y superior funcionalmente. Por otro lado, entre las limitaciones biol\u00f3gicas es importante evaluar la composici\u00f3n del medio de cultivo, el tipo de transplante y la v\u00eda de administraci\u00f3n. Todos estos par\u00e1metros habr\u00e1 que tenerlos en cuenta para garantizar el \u00e9xito terap\u00e9utico. en este trabajo inicialmente se caracterizaron los principales par\u00e1metros que pueden afectar a la elaboraci\u00f3n de las microc\u00e1psulas utilizando un goteador electrost\u00e1tico, para posteriormente elaborar formulaciones inmovilizando c\u00e9lulas c2c12 secretoras de eritropoyetina en microc\u00e1psulas de alginato-poli-l-lisina-alginato (apa) e implantarlas en ratones sing\u00e9nicos y alog\u00e9nicos por v\u00eda subcut\u00e1nea e intraperitoneal. Independientemente del tipo de hu\u00e9sped y de la v\u00eda de administraci\u00f3n, los niveles de hematocrito se mantuvieron significativamente elevados respecto al control hasta el d\u00eda 98 post-implante.  adem\u00e1s se evalu\u00f3 la posible utilizaci\u00f3n de la alb\u00famina s\u00e9rica humana (ash) para sustituir el suero bovino fetal (sbf) en el medio de cultivo para el mantenimiento de las c\u00e9lulas microencapsuladas, obteni\u00e9ndose que para las c\u00e9lulas c2c12 la ash ser\u00eda una posible alternativa al sbf para cortos per\u00edodos de tiempo. finalmente, se estudiaron diferentes policationes como la poli-l-ornitina, la poli-d-lisina y los oligoquitosanos como potenciales sustitutos de la pll, present\u00e1ndose estos \u00faltimos como una alternativa interesante al sistema cl\u00e1sico apa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Optimizacion de nuevos sistemas terapeuticos basados en la microencapsulacion de celulas utilizando la eritropoyetina como farmaco modelo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Optimizacion de nuevos sistemas terapeuticos basados en la microencapsulacion de celulas utilizando la eritropoyetina como farmaco modelo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz M\u00aa De Castro Matos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/10\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Mar\u00eda Hernandez Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Calonge cano <\/li>\n<li>Juan  Manuel Irache garreta (vocal)<\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<li>carmen Mar\u00eda Evora Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz M\u00aa De Castro Matos La aplicaci\u00f3n a nivel cl\u00ednico de la microencapsulaci\u00f3n de c\u00e9lulas requiere la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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