{"id":67813,"date":"2008-05-11T00:00:00","date_gmt":"2008-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-expresion-de-la-protea%c2%adna-kit-en-el-carcinoma-microca%c2%adtico-de-pulmon\/"},"modified":"2008-05-11T00:00:00","modified_gmt":"2008-05-11T00:00:00","slug":"valor-pronostico-de-la-expresion-de-la-protea%c2%adna-kit-en-el-carcinoma-microca%c2%adtico-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-expresion-de-la-protea%c2%adna-kit-en-el-carcinoma-microca%c2%adtico-de-pulmon\/","title":{"rendered":"Valor pron\u00f3stico de la expresi\u00f3n de la prote\u00edna kit en el carcinoma microc\u00edtico de pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Mar\u00eda Lopez Martin <\/strong><\/h2>\n<p>Introducci\u00f3n: el carcinoma microc\u00edtico de pulm\u00f3n (cmp) supone el 20 -25  del total de los c\u00e1nceres de pulm\u00f3n. Aparece de forma casi exclusiva en fumadores y se caracteriza por una r\u00e1pida tasa de duplicaci\u00f3n tumoral, alta fracci\u00f3n de crecimiento y por  presentar tendencia al desarrollo precoz de met\u00e1stasis a distancia. A pesar de su alta quimio y radiosensibilidad la supervivencia a largo plazo es excepcional. Un conocimiento m\u00e1s profundo de los eventos moleculares que subyacen al desarrollo de la  enfermedad es necesario para mejorar la estrategia terap\u00e9utica y la evoluci\u00f3n de los pacientes con esta enfermedad. La prote\u00edna kit se expresa en el cmp, y su actividad quinasa se ha implicado en la patog\u00e9nesis de diversos tumores, entre ellos el cm p. El objetivo de esta tesis fue determinar la preValencia de la expresi\u00f3n de kit en el cmp evaluar su posible impacto pron\u00f3stico.  m\u00e9todos: se realiz\u00f3 un an\u00e1lisis inmunohistoqu\u00edmico de 204 muestras de cmp de pacientes tratados en nuestro centro para  determinar la expresi\u00f3n de la prote\u00edna kit. Se evalu\u00f3 la relaci\u00f3n entre la expresi\u00f3n de kit y los par\u00e1metros cl\u00ednico-biol\u00f3gicos m\u00e1s relevantes. Se realiz\u00f3 un an\u00e1lisis univariante y multivariante para determinar el valor pron\u00f3stico de esta expresi\u00f3n.     resultados: se observ\u00f3 expresi\u00f3n de kit en 149 de las 204 muestras estudiadas (73 ). La expresi\u00f3n de kit se asoci\u00f3 con la enfermedad avanzada y con una disminuci\u00f3n en la incidencia de met\u00e1stasis \u00f3seas. No se observaron diferencias en el tiempo a la progresi\u00f3n de la enfermedad (9,1  versus 6,2  a 3 a\u00f1os, p=0,6) ni en la supervivencia global (10,7  versus 6,9  a 3 a\u00f1os, p=0,37) entre los pacientes con tumores kit positivos versus los pacientes con tumores kit negativos, respectivamente. El an\u00e1 lisis multivariante mostr\u00f3 que el sexo, el estadio tumoral, los valores de alb\u00famina s\u00e9rica y la respuesta al tratamiento fueron los \u00fanicos factores pron\u00f3sticos independientes para supervivencia.   conclusi\u00f3n: la prote\u00edna kit se expresa en un alto por centaje de los carcinomas microc\u00edticos de pulm\u00f3n. Sin embargo, en nuestra poblaci\u00f3n de estudio, la expresi\u00f3n de la prote\u00edna kit no presento un impacto significativo en la supervivencia de los pacientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la expresi\u00f3n de la prote\u00edna kit en el carcinoma microc\u00edtico de pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la expresi\u00f3n de la prote\u00edna kit en el carcinoma microc\u00edtico de pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Mar\u00eda Lopez Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Enr\u00edquez De Salamanca Lorente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>julio De la morena fern\u00e1ndez (vocal)<\/li>\n<li>\u00e1ngel L\u00f3pez encuentra (vocal)<\/li>\n<li>ramon Colomer bosch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Mar\u00eda Lopez Martin Introducci\u00f3n: el carcinoma microc\u00edtico de pulm\u00f3n (cmp) supone el 20 -25 del total 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