{"id":67815,"date":"2008-05-11T00:00:00","date_gmt":"2008-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-zofenopril-sobre-el-estres-oxidativo-y-el-remodelado-cardiovascular-en-ratas-hipertensas\/"},"modified":"2008-05-11T00:00:00","modified_gmt":"2008-05-11T00:00:00","slug":"efectos-de-zofenopril-sobre-el-estres-oxidativo-y-el-remodelado-cardiovascular-en-ratas-hipertensas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-cardiovascular\/efectos-de-zofenopril-sobre-el-estres-oxidativo-y-el-remodelado-cardiovascular-en-ratas-hipertensas\/","title":{"rendered":"Efectos de zofenopril sobre el estr\u00e9s oxidativo y el remodelado cardiovascular en ratas hipertensas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam G\u00f3mez Roso <\/strong><\/h2>\n<p>En este trabajo se estudi\u00f3 el efecto del tratamiento cr\u00f3nico con zofenopril sobre las alteraciones cardiovasculares que se presentan en la hipertensi\u00f3n arterial. zofenopril se administr\u00f3 a ratas espont\u00e1neamente hipertensas durante 2 o 3 meses a las dosis de 0,5 y 10 mg\/kg\/d\u00eda y se estudi\u00f3, adem\u00e1s, si los efectos se manten\u00edan un mes despu\u00e9s de retirar el tratamiento. a lo largo del estudio se produjo un incremento progresivo de la presi\u00f3n en los animales control que no se observ\u00f3 en el grupo tratado con 0,5 mg\/kg\/d\u00eda. El tratamiento con 10 mg\/kg\/d\u00eda redujo la presi\u00f3n arterial sist\u00f3lica de manera significativa, efecto que se mantiene parcialmente tras la retirada del f\u00e1rmaco. el tratamiento mejor\u00f3 la funcionalidad vascular, tanto en arterias de resistencia como de conductancia. Los experimentos realizados en arteria aorta indican que este efecto se debe, por una parte, a una menor contribuci\u00f3n de prostanoides contracturantes y por otra a la menor producci\u00f3n de radicales super\u00f3xido, que hemos observado tanto \u00abin vivo\u00bb como \u00abin vitro\u00bb. zofenopril reduce la hipertrofia renal, la fibrosis e hipertrofia cardiaca y revierte las alteraciones de vasos de conductancia y de resistencia producidas por la hipertensi\u00f3n. Estos efectos se favorecen por la elevada lipofilia del f\u00e1rmaco que da lugar a la inhibici\u00f3n de la eca tisular, incluso con la dosis m\u00e1s baja. la reducci\u00f3n de la hipertrofia cardiaca y vascular, as\u00ed como la mejor\u00eda en la funci\u00f3n endotelial se mantienen tras la retirada del tratamiento con 10 mg\/kg\/d\u00eda. algunos efectos de zofenopril son independientes de su capacidad para inhibir la formaci\u00f3n de angiotensina ii ya que, previene la p\u00e9rdida de relajaci\u00f3n a nivel vascular y el incremento en la deposici\u00f3n de col\u00e1geno a nivel cardiaco y evita parcialmente el incremento en la presi\u00f3n arterial sist\u00f3lica y en el \u00edndice de hipertrofia cardiaca en el modelo de hipertensi\u00f3n inducida por angiotensina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de zofenopril sobre el estr\u00e9s oxidativo y el remodelado cardiovascular en ratas hipertensas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de zofenopril sobre el estr\u00e9s oxidativo y el remodelado cardiovascular en ratas hipertensas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam G\u00f3mez Roso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa De Los \u00e1ngeles Sevilla Toral<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Orallo cambeiro <\/li>\n<li>Mar\u00eda  Jes\u00fas Alonso gordo (vocal)<\/li>\n<li>asunci\u00f3n Mor\u00e1n benito (vocal)<\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam G\u00f3mez Roso En este trabajo se estudi\u00f3 el efecto del tratamiento cr\u00f3nico con zofenopril sobre las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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