{"id":67825,"date":"2008-05-11T00:00:00","date_gmt":"2008-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-transporte-de-glucosa-en-adipocitos-insulina-cdk5-y-mbc2\/"},"modified":"2008-05-11T00:00:00","modified_gmt":"2008-05-11T00:00:00","slug":"el-transporte-de-glucosa-en-adipocitos-insulina-cdk5-y-mbc2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/el-transporte-de-glucosa-en-adipocitos-insulina-cdk5-y-mbc2\/","title":{"rendered":"El transporte de glucosa en adipocitos: insulina, cdk5 y mbc2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gemma Muru\u00e1is Mart\u00ednez <\/strong><\/h2>\n<p>La actividad de cdk5, kinasa at\u00edpica perteneciente a la familia cdks, era considerada hasta hace poco exclusiva del sistema nervioso. En esta tesis se demuestra que p35, activador de cdk5 se expresa durante el proceso de diferenciaci\u00f3n de fibroblastos 3t3-l1 en adipocitos al igual que glut4. Adem\u00e1s la actividad de cdk5 es estimulada por insulina y su inhibici\u00f3n por roscovitina o tras el silenciamiento en adipocitos inhibe el transporte de glucosa, cdk5 fosforila a mbc2, prote\u00edna relacionada con la familia de sinaptotagminas en la ser314 tras la estimulaci\u00f3n con insulina. Al igual que p35 los niveles de mbc2 se incrementan durante el proceso de diferenciaci\u00f3n de fibroblastos en adipocitos. Mbc2 es una prote\u00edna mayoritaria de membrana plasm\u00e1tica y hdm, que consta de 5 dominios c2 caracterizados por la uni\u00f3n a calcio y\/o fosfol\u00edpidos mostrando una uni\u00f3n preferente al \u00e1cido fosfatidico cuando las c\u00e9lulas son mantenidas en condiciones basales. Mbc2 interacciona con glut4 de manera dependiente de insulina, produciendo la hormona la disociaci\u00f3n del complejo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El transporte de glucosa en adipocitos: insulina, cdk5 y mbc2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El transporte de glucosa en adipocitos: insulina, cdk5 y mbc2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gemma Muru\u00e1is Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>sandoval Rodr\u00edguez Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Gonz\u00e1lez casta\u00f1o <\/li>\n<li>josefa predestinaci\u00f3n Garc\u00eda ruiz (vocal)<\/li>\n<li>albert Pol sorolla (vocal)<\/li>\n<li>Antonio Zorzano olarte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gemma Muru\u00e1is Mart\u00ednez La actividad de cdk5, kinasa at\u00edpica perteneciente a la familia cdks, era considerada hasta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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