{"id":67987,"date":"2018-03-09T22:56:26","date_gmt":"2018-03-09T22:56:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-en-la-expresion-de-protea%c2%adnas-proinflamatorias-por-el-tratamiento-antiprombotico-en-el-sa%c2%adndrome-coronario-agudo\/"},"modified":"2018-03-09T22:56:26","modified_gmt":"2018-03-09T22:56:26","slug":"modificaciones-en-la-expresion-de-protea%c2%adnas-proinflamatorias-por-el-tratamiento-antiprombotico-en-el-sa%c2%adndrome-coronario-agudo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-en-la-expresion-de-protea%c2%adnas-proinflamatorias-por-el-tratamiento-antiprombotico-en-el-sa%c2%adndrome-coronario-agudo\/","title":{"rendered":"Modificaciones en la expresi\u00f3n de prote\u00ednas proinflamatorias por el tratamiento antipromb\u00f3tico en el s\u00edndrome coronario agudo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Sacristan Redondo <\/strong><\/h2>\n<p>El s\u00edndrome coronario agudo es una de las principales causas de muerte en las sociedades occidentales. La funci\u00f3n plaquetaria est\u00e1 directamente relacionada tanto con los fen\u00f3menos tromb\u00f3ticos como con distintos procesos inflamatorios desencadenados d urante la fase aguda del s\u00edndrome coronario. En esta tesis doctoral se ha evaluado el papel de la plaqueta y del tratamiento antiplaquetario en distintos procesos inflamatorios desencadenados durante un s\u00edndrome coronario agudo tanto en pacientes com o en distintos modelos animales, utilizando t\u00e9cnicas de biolog\u00eda molecular tradicionales y t\u00e9cnicas prote\u00f3micas. Distintos experimentos han mostrado como la endotelina-1 (et-1) produjo en el miocardio y en los leucocitos circulantes de cobayas un aum ento de la expresi\u00f3n de prote\u00ednas proinflamatorias y activaci\u00f3n plaquetaria. El bloqueo de los receptores gp iib\/iiia plaquetarios redujo la acci\u00f3n proinflamatoria de et-1 demostrando que las plaquetas participan en la respuesta inflamatoria mediada por et-1. La evaluaci\u00f3n de la respuesta inflamatoria en conejos blancos nueva zelanda durante una situaci\u00f3n de isquemia coronaria tambi\u00e9n mostr\u00f3 un papel directo de la plaqueta en los procesos inflamatorios de la pared vascular isqu\u00e9mica. Por el cont rario, en los estudios realizados en pacientes tras el implante de un stent coronario se observ\u00f3 que dos pautas distintasde de tratamiento antiplaquetario produjeron un distinto grado de inhibici\u00f3n de los receptores gp iib\/iiia plaquetarios, lo cual no se vio acompa\u00f1ado de diferencias en la expresi\u00f3n de prote\u00ednas proinflamatorias ni en el proteoma plasm\u00e1tico de dichos pacientes. Sin embargo, el contenido proteico de las plaquetas de pacientes en el momento de sufrir un s\u00edndrome coronario agudo e s distinto es distinto al de individuos control lo que sugiere que, antes de producirse el evento coronario agudo, el megacariocito podr\u00eda estar generando plaquetas diferentes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones en la expresi\u00f3n de prote\u00ednas proinflamatorias por el tratamiento antipromb\u00f3tico en el s\u00edndrome coronario agudo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones en la expresi\u00f3n de prote\u00ednas proinflamatorias por el tratamiento antipromb\u00f3tico en el s\u00edndrome coronario agudo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Sacristan Redondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Barrientos guzm\u00e1n <\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<li>Luis alfonso Rico  zalba (vocal)<\/li>\n<li>guillermo Mo\u00f1ux ducaju (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Sacristan Redondo El s\u00edndrome coronario agudo es una de las principales causas de muerte en las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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