{"id":68007,"date":"2018-03-09T22:56:30","date_gmt":"2018-03-09T22:56:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-factores-pronosticos-geneticos-de-la-leucemia-linfatica-cronica-e-identificacion-de-nuevos-marcadores-moleculares-con-relevancia-cla%c2%adnica\/"},"modified":"2018-03-09T22:56:30","modified_gmt":"2018-03-09T22:56:30","slug":"estudio-de-los-factores-pronosticos-geneticos-de-la-leucemia-linfatica-cronica-e-identificacion-de-nuevos-marcadores-moleculares-con-relevancia-cla%c2%adnica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hemopatologia\/estudio-de-los-factores-pronosticos-geneticos-de-la-leucemia-linfatica-cronica-e-identificacion-de-nuevos-marcadores-moleculares-con-relevancia-cla%c2%adnica\/","title":{"rendered":"Estudio de los factores pron\u00f3sticos gen\u00e9ticos de la leucemia linf\u00e1tica cr\u00f3nica e identificaci\u00f3n de nuevos marcadores moleculares con relevancia cl\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 \u00e1ngel Hern\u00e1ndez Rivas <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os, el conocimiento de la leucemia linf\u00e1tica cr\u00f3nica (llc) ha experimentado un gran progreso y, en el campo de los factores pron\u00f3sticos, tanto las t\u00e9cnicas de hibridaci\u00f3n in situ fluorescente, el estado mutacional del gen de la cadena pesada de las inmunoglobulinas (igvh) y la expresi\u00f3n de cd38 y el zap-70 han supuesto un gran avance. A\u00fan as\u00ed, hay pocas series publicadas que analicen un n\u00famero amplio de pacientes que correlacionen los datos biol\u00f3gicos y el curso cl\u00ednico. Nuestros resultados confirman el valor pron\u00f3stico de los estudios gen\u00e9tico-moleculares en la llc, por lo que el an\u00e1lisis de las alteraciones cromos\u00f3micas en 11q, cromosoma 12, 13q, 14q32 y 17p, as\u00ed como el estudio de las mutaciones som\u00e1ticas del gen igvh, son pruebas necesarias a realizar en la valoraci\u00f3n cl\u00ednica, terap\u00e9utica y pron\u00f3stica de esta enfermedad. Adem\u00e1s, la identificaci\u00f3n del segmento gen\u00e9tico vh puede a\u00f1adir informaci\u00f3n adicional e independiente al estado mutacional de igvh el subgrupo de pacientes con la traslocaci\u00f3n 14q32 debe incluirse en la clasificaci\u00f3n jer\u00e1rquica entre los riesgos intermedio y desfavorable. Por otra parte, los enfermos con llc y un n\u00famero alto de p\u00e9rdidas en el cromosoma 13q presentan una menor supervivencia global y tiempo hasta la progresi\u00f3n que los que tienen trisom\u00eda 12, citogen\u00e9tica normal o un porcentaje bajo de c\u00e9lulas con 13q-. Desde el punto de vista biol\u00f3gico, los pacientes con llc y un n\u00famero alto de p\u00e9rdidas en 13q presentan m\u00e1s proliferaci\u00f3n y menos apoptosis en los perfiles de expresi\u00f3n g\u00e9nicos, lo que podr\u00eda justificar su peor pron\u00f3stico. Por \u00faltimo, los pacientes con llc, de manera especial los casos con p\u00e9rdidas en 13q, se caracterizan por la sobreexpresi\u00f3n del producto del proto-oncog\u00e9n vav. Es la primera ocasi\u00f3n en la que la expresi\u00f3n disregulada de este proto-oncog\u00e9n se ha comunicado en una enfermedad hematol\u00f3gica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los factores pron\u00f3sticos gen\u00e9ticos de la leucemia linf\u00e1tica cr\u00f3nica e identificaci\u00f3n de nuevos marcadores moleculares con relevancia cl\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los factores pron\u00f3sticos gen\u00e9ticos de la leucemia linf\u00e1tica cr\u00f3nica e identificaci\u00f3n de nuevos marcadores moleculares con relevancia cl\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 \u00e1ngel Hern\u00e1ndez Rivas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Mar\u00eda Hernandez Rivas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Rios gonzalez <\/li>\n<li>Ana Villegas mart\u00ednez (vocal)<\/li>\n<li>evaristo Feliu frasnedo (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Moraleda jim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 \u00e1ngel Hern\u00e1ndez Rivas En los \u00faltimos a\u00f1os, el conocimiento de la leucemia linf\u00e1tica cr\u00f3nica (llc) ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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