{"id":68066,"date":"2018-03-09T22:56:33","date_gmt":"2018-03-09T22:56:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/selection-and-linkage-disequilibrium-tests-under-complex-demographies-and-ascertainment-bias\/"},"modified":"2018-03-09T22:56:33","modified_gmt":"2018-03-09T22:56:33","slug":"selection-and-linkage-disequilibrium-tests-under-complex-demographies-and-ascertainment-bias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/selection-and-linkage-disequilibrium-tests-under-complex-demographies-and-ascertainment-bias\/","title":{"rendered":"Selection and linkage disequilibrium tests under complex demographies and ascertainment bias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Ram\u00edrez Soriano <\/strong><\/h2>\n<p>El estudio de la variaci\u00f3n gen\u00f3mica puede ayudarnos a entender la historia demogr\u00e1fica de las poblaciones y los eventos de selecci\u00f3n que han influido sobre ellas. Normalmente esto se hace mediante los tests de neutralidad, una herramienta estad\u00edstica que permite detectar desviaciones de la neutralidad mediante la comparaci\u00f3n de los resultados emp\u00edricos obtenidos por un estad\u00edstico a partir de una muestra de adn, contra una distribuci\u00f3n neutra simulada de dicho estad\u00edstico. Esta metodolog\u00eda tiene algunas limitaciones, principalmente relacionadas con (a) la variaci\u00f3n en la que se basa el test, (b) la misma metodolog\u00eda de uso de los estad\u00edsticos de neutralidad y (c) la tecnolog\u00eda usada para obtener informaci\u00f3n de las secuencias de adn. En los cuatro art\u00edculos presentados en esta tesis he abordado todos estos problemas. Respecto al primero he analizado el efecto que las desviaciones de la neutralidad, como la recombinaci\u00f3n o la demograf\u00eda, tienen sobre el poder de los estad\u00edsticos de neutralidad. En lo que refiere a la metodolog\u00eda, he estudiado si la incertidumbre en la reconstrucci\u00f3n de los datos de resecuenciaci\u00f3n tiene alg\u00fan efecto en el poder de los tests cuando se comparan contra datos de simulaci\u00f3n. Finalmente, los dos \u00faltimos trabajos abordan los problemas que surgen cuando se usan genotipos en lugar de datos de resecuenciaci\u00f3n, y proponen alternativas para el an\u00e1lisis de estos datos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Selection and linkage disequilibrium tests under complex demographies and ascertainment bias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Selection and linkage disequilibrium tests under complex demographies and ascertainment bias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Ram\u00edrez Soriano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Calafell Maj\u00f3<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: montserrat Aguade porres <\/li>\n<li>alfredo Ruiz panadero (vocal)<\/li>\n<li>rasmus Nielsen (vocal)<\/li>\n<li>\u00f3scar Lao grueso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Ram\u00edrez Soriano El estudio de la variaci\u00f3n gen\u00f3mica puede ayudarnos a entender la historia demogr\u00e1fica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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