{"id":68168,"date":"2018-03-09T22:56:37","date_gmt":"2018-03-09T22:56:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-influencia-del-tratamiento-con-infa-sobre-el-receptor-ifnar-en-pacientes-con-esclerosis-multiple-y-su-relacion-con-la-eficacia-terapeutica\/"},"modified":"2018-03-09T22:56:37","modified_gmt":"2018-03-09T22:56:37","slug":"estudio-de-la-influencia-del-tratamiento-con-infa-sobre-el-receptor-ifnar-en-pacientes-con-esclerosis-multiple-y-su-relacion-con-la-eficacia-terapeutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/estudio-de-la-influencia-del-tratamiento-con-infa-sobre-el-receptor-ifnar-en-pacientes-con-esclerosis-multiple-y-su-relacion-con-la-eficacia-terapeutica\/","title":{"rendered":"Estudio de la influencia del tratamiento con inf\u00c2\u00bf sobre el receptor ifnar en pacientes con esclerosis  multiple y su relacion con la eficacia terapeutica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Oliver Martos <\/strong><\/h2>\n<p>El inf\u00edY esta indicado en pacientes con esclerosis m\u00faltiple que cursan con la forma rr, reduciendo el numero de brotes y la progresi\u00f3n en la escala edss. Pero existe un 30 % de pacientes que no experimentan una mejor\u00eda con dicho tratamiento. Dado que el inf\u00edY act\u00faa a trav\u00e9s de su receptor de superficie celular (ifnar), se midi\u00f3 la expresi\u00f3n, a nivel de mensajero, en pbmc de pacientes con em por pcr a tiempo real y de prote\u00ednas involucradas en la  cascada de se\u00f1alizaci\u00f3n del ifn (via jak-stat) en las subpoblaciones linfocitarias t (cd4 y cd8) y monocitos. La asociaci\u00f3n de estos resultados con la respuesta al tratamiento podr\u00eda ayudar a discriminar de forma m\u00e1s adecuada aquellos enfermos en los que el tratamiento va a resultar poco eficaz, optimizando los recursos sanitarios, o aun mejor, elaborar estrategias que aumenten la eficacia de este f\u00e1rmaco. Se analizo tambi\u00e9n el desarrollo de anticuerpos neutralizantes frente a inf\u00edY a lo largo de cinco a\u00f1os de tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la influencia del tratamiento con inf\u00c2\u00bf sobre el receptor ifnar en pacientes con esclerosis  multiple y su relacion con la eficacia terapeutica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la influencia del tratamiento con inf\u00c2\u00bf sobre el receptor ifnar en pacientes con esclerosis  multiple y su relacion con la eficacia terapeutica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Oliver Martos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar Fernandez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Alcina madue\u00f1o <\/li>\n<li>guillermo Estivill torr\u00fas (vocal)<\/li>\n<li>francisca Romero crespo (vocal)<\/li>\n<li>victoria eugenia Fernandez fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Oliver Martos El inf\u00edY esta indicado en pacientes con esclerosis m\u00faltiple que cursan con la forma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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