{"id":68222,"date":"2018-03-09T22:56:41","date_gmt":"2018-03-09T22:56:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/study-of-the-molecular-changes-in-the-retina-with-glaucoma-and-leber-congenital-amaurosis-lca-effect-of-the-gene-therapy\/"},"modified":"2018-03-09T22:56:41","modified_gmt":"2018-03-09T22:56:41","slug":"study-of-the-molecular-changes-in-the-retina-with-glaucoma-and-leber-congenital-amaurosis-lca-effect-of-the-gene-therapy","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/morfologia-celular\/study-of-the-molecular-changes-in-the-retina-with-glaucoma-and-leber-congenital-amaurosis-lca-effect-of-the-gene-therapy\/","title":{"rendered":"Study of the molecular changes in the retina with glaucoma and leber congenital amaurosis (lca): effect of the gene therapy"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Hernandez Sanchez <\/strong><\/h2>\n<p>La amaurosis congenita de leber (acl) y el glaucoma son dos enfermedades relacionadas con la degeneraci\u00f3n de la retina. Aunque ambos s\u00edndromes poseen un origen diferente en la retina, en este trabajo hemos demostrado como diferentes subtipos celulares est\u00e1n implicados en la misma v\u00eda de da\u00f1o. De este modo consideramos que un da\u00f1o local en la retina, posee un gran impacto en subtipos espec\u00edficos celulares. Para estudiar estas dos alteraciones, hemos utilizado dos modelos animales que desarrollan la enfermedad de forma paralela a humanos. As\u00ed mismo, hemos utilizado m\u00e9todos en inmunohistoqu\u00edmica con diferentes marcadores moleculares para analizar las c\u00e9lulas fotorreceptoras, neuronas de la retina interna, capas plexiformes y glia. En este trabajo demostramos como las v\u00eda de las c\u00e9lulas bipolares de bast\u00f3n (bipolar de bast\u00f3n- amacrinas tipo a-ii) adem\u00e1s de la glia, est\u00e1n implicadas en enfermedades neurodegenerativas de la retina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Study of the molecular changes in the retina with glaucoma and leber congenital amaurosis (lca): effect of the gene therapy<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Study of the molecular changes in the retina with glaucoma and leber congenital amaurosis (lca): effect of the gene therapy <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Hernandez Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Vecino Cordero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Martinez millan <\/li>\n<li>sansar Sharma (vocal)<\/li>\n<li>gustavo Aguirre (vocal)<\/li>\n<li>Miguel Castlo-branco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Hernandez Sanchez La amaurosis congenita de leber (acl) y el glaucoma son dos enfermedades relacionadas con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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