{"id":68231,"date":"2018-03-09T22:56:41","date_gmt":"2018-03-09T22:56:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-aceite-de-oliva-virgen-sobre-el-efecto-de-aspirina-en-los-procesos-de-isquemia-cerebral-y-retiniana-en-la-diabetes-mellitus-experimental\/"},"modified":"2018-03-09T22:56:41","modified_gmt":"2018-03-09T22:56:41","slug":"influencia-del-aceite-de-oliva-virgen-sobre-el-efecto-de-aspirina-en-los-procesos-de-isquemia-cerebral-y-retiniana-en-la-diabetes-mellitus-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/epidemiologia\/influencia-del-aceite-de-oliva-virgen-sobre-el-efecto-de-aspirina-en-los-procesos-de-isquemia-cerebral-y-retiniana-en-la-diabetes-mellitus-experimental\/","title":{"rendered":"Influencia del aceite de oliva virgen sobre el efecto de aspirina en los procesos de isquemia cerebral y retiniana en la diabetes mellitus experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Del R\u00edo Fern\u00e1ndez <\/strong><\/h2>\n<p>Debido a la mayor incidencia de isquemia cerebral y retiniana en la diabetes mellitus y la importancia que la inhibici\u00f3n de la agregaci\u00f3n plaquetaria y del estr\u00e9s oxidativo tisular en estos procesos, se plante\u00f3 el presente estudio con el objetivo principal de valorar el efecto de una fuente alimentaria de antioxidantes (aceite de oliva virgen) sobre el conocido potencial antitromb\u00f3tico y antiisqu\u00e9mico del \u00e1cido acetilsalic\u00edlico (aspirina). Para ello se utiliz\u00f3 el modelo experimental de diabetes en ratas inducida por estreptozotocina, contemplando tres meses de evoluci\u00f3n. Se constituyeron cinco grupos de estudio: un grupo control normogluc\u00e9mico, uno control diab\u00e9tico, otro diab\u00e9tico tratado con 2 mg\/kg\/d\u00eda p.O. De aspirina, otro tratado con 0.5 ml\/kg\/d\u00eda de aceite de oliva virgen (aov) y otro en el que se asoci\u00f3 aspirina y aov a las dosis antes indicadas. Se determinaron las siguientes variables: a) variables plaquetarias: intensidad m\u00e1xima de agregaci\u00f3n plaquetaria, s\u00edntesis de tromboxano; b) variables endoteliales: producci\u00f3n de prostaciclina y de \u00f3xido n\u00edtrico en anillos a\u00f3rticos; c) modelo experimental de hipoxia-reoxigenaci\u00f3n en cortes cerebrales, en los que se cuantificaron par\u00e1metros de estr\u00e9s oxidativo, ac\u00famulo de prostaglandinas, v\u00eda del \u00f3xido n\u00edtrico y muerte neuronal (actividad ldh); d) morfometr\u00eda retiniana tras inyecci\u00f3n intracarotidea de peroxidasa. Los animales diab\u00e9ticos sin tratamiento presentaron una hiperestimulaci\u00f3n plaquetaria, un d\u00e9ficit de sustancias antitromb\u00f3ticas vasculares, una mayor sensibilidad cerebral a los da\u00f1os bioqu\u00edmicos de la hipoxia-reoxigenaci\u00f3n y un claro estado de isquemia retiniana. La administraci\u00f3n de los compuestos estudiados modifico este esquema. La administraci\u00f3n de aspirina inhibi\u00f3 claramente la funci\u00f3n plaquetaria y fren\u00f3 la isquemia retiniana. La administraci\u00f3n de aov asimismo fren\u00f3 la funci\u00f3n plaquetaria, estimul\u00f3 la producci\u00f3n vascular de prostaciclina y protegi\u00f3 al cerebro del da\u00f1o oxidativo en la hipoxia-reoxigenaci\u00f3n, reduciendo tambi\u00e9n el grado de isquemia retiniana. La asociaci\u00f3n de aspirina y aov produjo un incremento en los principales par\u00e1metros determinados, en el sentido de ofrecer una mejor protecci\u00f3n bioqu\u00edmica y morfol\u00f3gica tanto en el tejido cerebral como en el retiniano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del aceite de oliva virgen sobre el efecto de aspirina en los procesos de isquemia cerebral y retiniana en la diabetes mellitus experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del aceite de oliva virgen sobre el efecto de aspirina en los procesos de isquemia cerebral y retiniana en la diabetes mellitus experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Del R\u00edo Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: matilde Sierra vega <\/li>\n<li>Antonio Moreno guerrero (vocal)<\/li>\n<li>Mar\u00eda dolores Pinazo dur\u00e1n (vocal)<\/li>\n<li>v\u00edctor Smith fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Del R\u00edo Fern\u00e1ndez Debido a la mayor incidencia de isquemia cerebral y retiniana en la diabetes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1086,7834],"tags":[8063,24766,146446,24997,149874,149875],"class_list":["post-68231","post","type-post","status-publish","format-standard","hentry","category-epidemiologia","category-malaga","tag-antonio-moreno-guerrero","tag-jose-antonio-gonzalez-correa","tag-maria-dolores-pinazo-duran","tag-matilde-sierra-vega","tag-sergio-del-rio-fernandez","tag-victor-smith-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68231"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68231\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}