{"id":68351,"date":"2018-03-09T22:56:48","date_gmt":"2018-03-09T22:56:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunidad-innata-y-adquirida-en-hepatopatia-cronica-papel-de-la-translocacion-bacteriana-intestinal\/"},"modified":"2018-03-09T22:56:48","modified_gmt":"2018-03-09T22:56:48","slug":"inmunidad-innata-y-adquirida-en-hepatopatia-cronica-papel-de-la-translocacion-bacteriana-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cadiz\/inmunidad-innata-y-adquirida-en-hepatopatia-cronica-papel-de-la-translocacion-bacteriana-intestinal\/","title":{"rendered":"Inmunidad innata y adquirida en hepatopatia cronica: papel de la translocacion bacteriana intestinal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  De Las Mercedes Marquez Coello <\/strong><\/h2>\n<p>La cirrosis hep\u00e1tica es una enfermedad que no solo afecta al h\u00edgado, sino que presenta adem\u00e1s alteraciones de los sistemas vascular, inflamatorio e inmune. las alteraciones vasculares se caracterizan por hipertensi\u00f3n portal, ascitis y fmalmente s\u00edndrome hepatorenal. En cuanto a las alteraciones inmunes, en los enfermos cirr\u00f3ticos se ha detectado una mayor predisposici\u00f3n a infecciones bacterianas debidas a anomalias del sistema inmunitario. estudios previos han demostrado anomal\u00edas en la funci\u00f3n macr\u00f3fagica, linfocitaria t y b, y citot\u00f3xica natural. Los enfermos con cirrosis hep\u00e1tica presentan alteraciones en las funcines de linfocitos t caracterizadas por una disminuci\u00f3n de la proliferacion ante est\u00edmulos pol\u00edclonales que act\u00faan sobre su membrana pl\u00e1smatica, y una disminuci\u00f3n de la actividad citotoxica natural, al mismo tiempo que un incremento de la s\u00edntesis de factores que cooperan con los linfocitos b en la s\u00edntesis de inmunoglobulinas, es decir la hiperinmunoglobulinemia detectada con frecuencia en estos individuos. estas premisas nos llevan a formulamos como hip\u00f3tesis si las alteraciones del sistema inmune son debidas a la trans bacteriana, fen\u00f3meno que favorece el paso de microorganismos a los ganglios linf\u00e1ticos mesent\u00e9ricos y de ah\u00ed al torrente circulatorio. Dicha translocacion es consecuencia de la inmunosupresion que caracteriza a esta enfermedad. el estudio ha analizado en una muestra de 40 enfermos con cirrosis hep\u00e1tica las modificaciones en el n\u00famero y en la expresi\u00f3n de ant\u00edgenos asociados a funci\u00f3n de monocitos y de las grandes poblaciones linfocitarias en sangre perif\u00e9rica. y hemos podido relacionar las posibles alteraciones detectadas con una s\u00e9rie de factores que de modo ya cl\u00e1sico o reciente se han asoiciado a esta patolog\u00eda: causa viral o toxica, estadio compensado o descompensado de la cirrosis o aumento de la permeabilidad intestinal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunidad innata y adquirida en hepatopatia cronica: papel de la translocacion bacteriana intestinal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunidad innata y adquirida en hepatopatia cronica: papel de la translocacion bacteriana intestinal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  De Las Mercedes Marquez Coello <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Clotilde Fernandez Gutierrez Del Alamo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>claudio Rodr\u00edguez ramos (vocal)<\/li>\n<li>Manuel Rodriguez zapata (vocal)<\/li>\n<li>Jos\u00e9 Antonio Brieva romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda De Las Mercedes Marquez Coello La cirrosis hep\u00e1tica es una enfermedad que no solo afecta al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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