{"id":68388,"date":"2008-01-12T00:00:00","date_gmt":"2008-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hormonas-esteroideas-circulantes-en-pacientes-postmenopausicas-con-cancer-de-mama\/"},"modified":"2008-01-12T00:00:00","modified_gmt":"2008-01-12T00:00:00","slug":"hormonas-esteroideas-circulantes-en-pacientes-postmenopausicas-con-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/hormonas-esteroideas-circulantes-en-pacientes-postmenopausicas-con-cancer-de-mama\/","title":{"rendered":"Hormonas esteroideas circulantes en pacientes postmenop\u00e1usicas con c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Martin Gutierrez <\/strong><\/h2>\n<p>Introducci\u00f3n: el c\u00e1ncer de mama es la primera causa de muerte por c\u00e1ncer en las mujeres de los pa\u00edses industrializados y su incidencia se est\u00e1 incrementando a raz\u00f3n de un 1-2% anual. En espa\u00f1a se diagnostican 14.000 nuevos casos de c\u00e1ncer de mama al a\u00f1o. Existe evidencia cient\u00edfica de que las hormonas esteroideas aumentan el riesgo de c\u00e1ncer de mama en pacientes postmenop\u00e1usicas, debido a su funci\u00f3n promotora sobre las c\u00e9lulas del epitelio mamario.  objetivo del estudio: observar si existe correlaci\u00f3n entre las hormonas esteroideas circulantes y las caracter\u00edsticas cl\u00ednicas y biol\u00f3gicas del c\u00e1ncer de mama en un grupo de 161 mujeres postmenop\u00e1usicas con c\u00e1ncer de mama, diagnosticadas e intervenidas quir\u00fargicamente en la fundaci\u00f3n tejerina-centro de patolog\u00eda de la mama, de Madrid de 2000 a 2007. material y m\u00e9todos: se han cuantificado los niveles de fsh,lh, prolactina, estradiol y progesterona  mediante t\u00e9cnicas de emtinomio\u00edlixis. En las piezas tumorales, se ha determinado el tama\u00f1o, los grados histol\u00f3gico y n\u00faclear y la invasi\u00f3n anglionar y se han utilizado t\u00e9cnicas inmohistoqu\u00edmica, atometr\u00eda de flujo y transcripci\u00f3n reversa-reacci\u00f3n en cadena de la polimerasa, para el estudio de factores pron\u00f3sticos del c\u00e1ncer de mama (expresi\u00f3n de receptores hormonales, kig7, c-esb-b2, plodia, p53,vegg, box, bel-2, nup88 y genes de la familia rbm. resultados: hemos obtenido correlaci\u00f3n directa estad\u00edsticamente significativa entre los niveles circulantes de estradiol  y progesterona (p<0,0001 y r:0,42), fsh y lh (p<0,0001 y r:0,58), lh y prolactina (p: 0,041 y r:-0,16) e inversa entre estradiol y fsh (p:0,041 y r: -0,16). Hemos observado tambi\u00e9n una correlaci\u00f3n inversa estad\u00edsticamente significativa entre estradiol y c-esb-b2 (p:0,03 y r:-0,17) y cos (p:0,091 y r:-0,26). conclusiones: a pesar de que los estr\u00f3genos aumentan el riesgo del c\u00e1ncer de mama en pacientes postmenop\u00e1usicas, se asocian a un fenotipo menos agresivo y por lo tanto, mejor pron\u00f3stico.\n\n\n\n&nbsp;\n\n\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hormonas esteroideas circulantes en pacientes postmenop\u00e1usicas con c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hormonas esteroideas circulantes en pacientes postmenop\u00e1usicas con c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Martin Gutierrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rey juan carlos<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Schneider Fontan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Due\u00f1as diez <\/li>\n<li>Jaime Sanchez fernandez de la vega (vocal)<\/li>\n<li>Rafael Torrejon cardoso (vocal)<\/li>\n<li>raul Lucas escobar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Martin Gutierrez Introducci\u00f3n: el c\u00e1ncer de mama es la primera causa de muerte por c\u00e1ncer en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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