{"id":68535,"date":"2008-09-12T00:00:00","date_gmt":"2008-09-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-inhibicion-selectiva-de-la-ciclooxigenasa-2-en-la-prevencion-de-esofago-de-barret-y-adenocarcinoma-de-esofago\/"},"modified":"2008-09-12T00:00:00","modified_gmt":"2008-09-12T00:00:00","slug":"efecto-de-la-inhibicion-selectiva-de-la-ciclooxigenasa-2-en-la-prevencion-de-esofago-de-barret-y-adenocarcinoma-de-esofago","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-abdominal\/efecto-de-la-inhibicion-selectiva-de-la-ciclooxigenasa-2-en-la-prevencion-de-esofago-de-barret-y-adenocarcinoma-de-esofago\/","title":{"rendered":"Efecto de la inhibicion selectiva de la ciclooxigenasa-2 en la prevencion de esofago de barret y adenocarcinoma de esofago"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Morandeira Rivas <\/strong><\/h2>\n<p>Introducci\u00f3n: en los \u00faltimos a\u00f1os se ha producido un incremento en la incidencia de adenocarcinoma de es\u00f3fago (ace)_ estudios recientes sugieren que la ciclooxigenasa-2 (cox-2) est\u00e1 implicada en el proceso de adenocarcinog\u00e9nesis del es\u00f3fago y que los inhibidores de la cox-2 podr\u00edan ser efectivos-enla quimioprevenci\u00f3n del ace. hip\u00f3tesis: la inhibici\u00f3n selectiva de la cox-2 previene el desarrollo de metaplasia de baaett y\/o la progresi\u00f3n de es\u00f3fago de barrett a aden\u00f3carcinoma_ material y m\u00e9todos: modelo experimental de es\u00f3fago de barrett y adenocarcinoma en rata wistar mediante esofagoyeyunostom\u00eda (ey) con preservaci\u00f3n g\u00e1strica. Tras la ey, las ratas fueron aleatorizadas en 3 grupos: 1- control sin tratamiento; 2- tratamiento con inhibidor selectivo de cox-2 (mf-tryciclic) y 3- tratamiento con inhibidor no selectivo de cox (indometacina)_ en los tres grupos se sacrificaron animales en dos momentos en el tiempo, a los 2 y a los 4 meses_ los es\u00f3fagos fueron evaluados macro y microsc\u00f3picamente_ se anal \u00abv\u00f3 tambi\u00e9n la expresi\u00f3n de cox-1 y cox-2 (pcr a tiempo real y western blot) y los niveles de prostaglandina e2 (ria). Los niveles de droga en plasma se determinaron por iiplc- los resultados se evaluaron mediante an\u00e1lisis de covarianza para variables cuantitativas. Para las variables cualitativas se ajust\u00f3 un modelo log\u00edstico. resultados: la ey indujo un aumento significativo de los niveles de pge2 en el es\u00f3fago (67,9 \u00c2\u00b1 8 ng pge2\/gr tejido en ratas no operadas vs. 1332 \u00c2\u00b1328 ng\/gr ey 2\u00c2\u00b0 mes; 1121 \u00c2\u00b1 507 ey 4\u00c2\u00b0 mes;p<0.05), y aumento de expresi\u00f3n de cox-1 y cox 2- el tratamiento con indometacina redujo signifrcativamente los niveles de pge2 en es\u00f3fago a los 2 y 4 meses tras la intervenci\u00f3n respecto al grupo control sin tratamiento. El tratamiento con mf tricyclic no redujo los niveles de pge2 en es\u00f3fago, a pesar de que se alcanzaron niveles plasm\u00e1ticos de mf-tricyclic adecuados para inhibirla actividad cox-2. La administraci\u00f3n de mf tricyclic no modific\u00f3 el grado de inflamaci\u00f3n, ulceraci\u00f3n, presencia de metaplasia intestinal, ni de adenocarcinoma. La administraci\u00f3n de indometacina disminuy\u00f3 el porcentaje de mucosa ulcerada, la longitud de la metaplasia en continuidad, la incidencia de metaplasia alejada, la severidad de la displasia y la incidencia de adenocarcinoma de es\u00f3fago. conclusiones: la administraci\u00f3n de un inhibidor dual cox-1\/cox-2, indometacina, pero no de un inhibidor selectivo de cox-2, previene la progresi\u00f3n de esofagitis a es\u00f3fago de bairett y de \u00e9ste a adenocarcinoma en este modelo de reflujo gastrointestinal en la rata.\n\n\n\n&nbsp;\n\n\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la inhibicion selectiva de la ciclooxigenasa-2 en la prevencion de esofago de barret y adenocarcinoma de esofago<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la inhibicion selectiva de la ciclooxigenasa-2 en la prevencion de esofago de barret y adenocarcinoma de esofago <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Morandeira Rivas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ortego fernandez de retana <\/li>\n<li>Francisco Barreiro morandeira (vocal)<\/li>\n<li>ricardo Sainz samitier (vocal)<\/li>\n<li>daniel Del castillo dejardin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Morandeira Rivas Introducci\u00f3n: en los \u00faltimos a\u00f1os se ha producido un incremento en la incidencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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