{"id":68558,"date":"2008-10-12T00:00:00","date_gmt":"2008-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-fosfolipasas-a2-en-la-liberacion-de-acido-araquidonico-y-la-expresion-de-ciclooxigenasa-2-en-macrofagos-de-raton\/"},"modified":"2008-10-12T00:00:00","modified_gmt":"2008-10-12T00:00:00","slug":"papel-de-las-fosfolipasas-a2-en-la-liberacion-de-acido-araquidonico-y-la-expresion-de-ciclooxigenasa-2-en-macrofagos-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/lipidos\/papel-de-las-fosfolipasas-a2-en-la-liberacion-de-acido-araquidonico-y-la-expresion-de-ciclooxigenasa-2-en-macrofagos-de-raton\/","title":{"rendered":"Papel de las fosfolipasas a2 en la liberaci\u00f3n de \u00e1cido araquid\u00f3nico y la expresi\u00f3n de ciclooxigenasa-2 en macr\u00f3fagos de rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Violeta Ruip\u00e9rez Pr\u00e1danos <\/strong><\/h2>\n<p>En este trabajo se utilizan 10 agonistas de receptores toll-like para definir el papel de las fosfolipasas a2 en la liberaci\u00f3n de \u00e1cido araquid\u00f3nico en macr\u00f3fagos. El tratamiento de p388d1 y raw 264.7 con pirrofenona, inhibidor selectivo de la cpla2\u00c2\u00bf y escalaradial, inhibidor de la spla2, muestran que la contribuci\u00f3n de estas fosfolipasas a la liberaci\u00f3n de \u00e1cido araquid\u00f3nico depende del tlr a trav\u00e9s del que se est\u00e1 produciendo la activaci\u00f3n. No se observan cambios en la liberaci\u00f3n de \u00e1cido araquid\u00f3nico cuando se utiliza bel, inhibidor de la ipla2. adem\u00e1s se identifica la lisofosfatidilcolina como el mediador de la spla2-v implicado en la inducci\u00f3n de cox-2 en macr\u00f3fagos estimulados con lps. La inhibici\u00f3n de la spla2-v con rna de interferencia o con escalaradial bloquea la expresi\u00f3n de cox-2 y la activaci\u00f3n del factor de transcripci\u00f3n c-rel inducida por lps, y ambas se recuperan selectivamente con un an\u00e1logo no hidrolizable de lisofosfatidilcolina.  adicionalmente, el escalaradial evita la fosforilaci\u00f3n de erk1\/2 y cpla2\u00c2\u00bf en respuesta a la activaci\u00f3n a trav\u00e9s de tlrs, mecanismo que depende del receptor a trav\u00e9s del que se produce esta activaci\u00f3n, lo que indica un mecanismo de regulaci\u00f3n de la spla2-v y cpla2\u00c2\u00bf dependiente de tlr.  estos resultados sugieren un modelo en el que la cpla2\u00c2\u00bf es la principal responsable de la liberaci\u00f3n de \u00e1cido araquid\u00f3nico en macr\u00f3fagos. La spla2-v contribuye amplificando este proceso mediante la hidr\u00f3lisis de los fosfol\u00edpidos y la regulaci\u00f3n de la fosforilaci\u00f3n secuencial de erk1\/2 y cpla2\u00c2\u00bf. Por otro lado, la spla2-v hidroliza los fosfol\u00edpidos generando lisofosfatidilcolina, la cual regula la expresi\u00f3n de cox-2 por un mecanismo que implica la actividad transcripcional de c-rel.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las fosfolipasas a2 en la liberaci\u00f3n de \u00e1cido araquid\u00f3nico y la expresi\u00f3n de ciclooxigenasa-2 en macr\u00f3fagos de rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las fosfolipasas a2 en la liberaci\u00f3n de \u00e1cido araquid\u00f3nico y la expresi\u00f3n de ciclooxigenasa-2 en macr\u00f3fagos de rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Violeta Ruip\u00e9rez Pr\u00e1danos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Balsinde Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: silvia pilar L\u00f3pez burillo <\/li>\n<li>joan Claria enrich (vocal)<\/li>\n<li>gerard Bannenberg (vocal)<\/li>\n<li>Juan  Manuel Zapata hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Violeta Ruip\u00e9rez Pr\u00e1danos En este trabajo se utilizan 10 agonistas de receptores toll-like para definir el papel 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