{"id":68577,"date":"2018-03-09T23:12:50","date_gmt":"2018-03-09T23:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-anticuerpos-dirigidos-frente-al-virus-respiratorio-sincitial-humano-presentes-en-preparaciones-de-inmunoglobulinas-humanas\/"},"modified":"2018-03-09T23:12:50","modified_gmt":"2018-03-09T23:12:50","slug":"caracterizacion-de-anticuerpos-dirigidos-frente-al-virus-respiratorio-sincitial-humano-presentes-en-preparaciones-de-inmunoglobulinas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-anticuerpos-dirigidos-frente-al-virus-respiratorio-sincitial-humano-presentes-en-preparaciones-de-inmunoglobulinas-humanas\/","title":{"rendered":"Caracterizaci\u00f3n de anticuerpos dirigidos frente al virus respiratorio sincitial humano presentes en preparaciones de inmunoglobulinas humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Sastre Antoranz <\/strong><\/h2>\n<p>El virus respiratorio sincitial humano (vrsh) es un neumovirus, responsable de la mayoria de las infecciones graves del tracto respiratorio inferior en ni\u00f1os de corta edad. Tambi\u00e9n causa un n\u00famero importante de infecciones respiratorias en ancianos y en individuos inmunodeprimidos. Hasta el momento no se ha encontrado una vacuna efectiva contra el mismo, aunque se sabe que la administraci\u00f3n pasiva de anticuerpos neutralizantes, tanto monoclonales como policlonales en pacientes de alto riesgo (ni\u00f1os prematuros, inmunodeprimidos, con enfermedades cardiacas, broncopulmonares &#8230;) Representa un m\u00e9todo nuevo y efectivo de inmunoprofilaxis.  el objetivo de esta tesis ha sido la caracterizaci\u00f3n de ep\u00edtopos en las glicoprote\u00ednas f y g del virus, reconocidos por anticuerpos neutralizantes que se producen tras la infecci\u00f3n natural en humanos. Para ello se procedi\u00f3 al fraccionamiento de inmunoglobulinas humanas por cromatograf\u00eda de afinidad en columnas preparadas con prote\u00edna f, g o fragmentos de las mismas. Posteriormente se valor\u00f3 en las distintas fracciones el t\u00edtulo de anticuerpos anti- vrsh, as\u00ed como su capacidad de neutralizar la infecci\u00f3n viral. Como material de partida se dispuso de dos preparaciones comerciales de inmunoglobulinas purificadas de sueros de distintos individuos: respigam (rg) y flebogamma (fg).  los resultados presentados en esta tesis ofrecen la posibilidad de buscar nuevos anticuerpos dirigidos frente a ep\u00edtopos implicados en neutralizaci\u00f3n, que puedan utilizarse para el tratamiento profil\u00e1ctico y\/o terape\u00fatico de las infecciones por el vrsh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de anticuerpos dirigidos frente al virus respiratorio sincitial humano presentes en preparaciones de inmunoglobulinas humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de anticuerpos dirigidos frente al virus respiratorio sincitial humano presentes en preparaciones de inmunoglobulinas humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Sastre Antoranz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Melero Fondevilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ortin monton <\/li>\n<li>Jos\u00e9 Alcami pertejo (vocal)<\/li>\n<li>Rafael Blasco (vocal)<\/li>\n<li>txema Marim\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Sastre Antoranz El virus respiratorio sincitial humano (vrsh) es un neumovirus, responsable de la mayoria de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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