{"id":68597,"date":"2018-03-09T23:12:50","date_gmt":"2018-03-09T23:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hacia-una-sa%c2%adntesis-total-y-practica-de-la-tetrodotoxina\/"},"modified":"2018-03-09T23:12:50","modified_gmt":"2018-03-09T23:12:50","slug":"hacia-una-sa%c2%adntesis-total-y-practica-de-la-tetrodotoxina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/hacia-una-sa%c2%adntesis-total-y-practica-de-la-tetrodotoxina\/","title":{"rendered":"Hacia una s\u00edntesis total y pr\u00e1ctica de la tetrodotoxina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lidia Ozores Viturro <\/strong><\/h2>\n<p>En este trabajo se ha continuado los estudios que el grupo ven\u00eda realizando dirigidos a establecer una s\u00edntesis total y pr\u00e1ctica de la tetrodotoxina, una neurotoxona de origen natural de gran inter\u00e9s dada su actividad para bloquear la transmisi\u00f3n del impulso nervioso.  en resumen:  1,- se ha desarrollado un estudio exploratorio de una de las unidades estructurales caracter\u00edsticas de la tetrodotoxina, su unidad de guanidina.  2,- se han estudiado dos estrategias para la construcci\u00f3n del esqueleto carbonado de la toxina:  a,- a partir de la d-manosa se han preparado intermedios adecuados para ensayar reacciones radicalarias que nos permitieran construir simult\u00e1neamente el anillo ciclohex\u00e1nico y el centro cuaternario nitrogenado presentes en la tetrodotoxina.  b,- mediante una estrategia de anelaci\u00f3n de la 2,2-dimetil-1,3-dioxan-5-ona, a trav\u00e9s de su correspondiente enamina, con electr\u00f3filos bidentados hemos obtenido derivados ciclohex\u00e1nicos polihidroxilados muy prometedores como precursores reales avanzados, tanto de esta neurotoxina y sus an\u00e1logos como de otros productos naturales tales como la pancratistatina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hacia una s\u00edntesis total y pr\u00e1ctica de la tetrodotoxina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hacia una s\u00edntesis total y pr\u00e1ctica de la tetrodotoxina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lidia Ozores Viturro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Alonso Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sa\u00e1 rodriguez Jos\u00e9 Mar\u00eda <\/li>\n<li>mercedes Amat tus\u00f3n (vocal)<\/li>\n<li>joaquin Plumet ortega (vocal)<\/li>\n<li>Francisco Bermejo gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lidia Ozores Viturro En este trabajo se ha continuado los estudios que el grupo ven\u00eda realizando dirigidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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