{"id":68617,"date":"2018-03-09T23:12:50","date_gmt":"2018-03-09T23:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recuperacion-del-sistema-inmulologa%c2%adco-en-ninos-infectados-por-el-vih-1-efectos-de-la-terapia-antirretroviral\/"},"modified":"2018-03-09T23:12:50","modified_gmt":"2018-03-09T23:12:50","slug":"recuperacion-del-sistema-inmulologa%c2%adco-en-ninos-infectados-por-el-vih-1-efectos-de-la-terapia-antirretroviral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recuperacion-del-sistema-inmulologa%c2%adco-en-ninos-infectados-por-el-vih-1-efectos-de-la-terapia-antirretroviral\/","title":{"rendered":"Recuperaci\u00f3n del sistema inmulolog\u00edco en ni\u00f1os infectados por el vih-1 efectos de la terapia antirretroviral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Correa Rocha <\/strong><\/h2>\n<p>La principal consecuencisa de la infecci\u00f3n por el vih es una marcada depleci\u00f3n de linfocitos t cd4 que conduce a la inmunodeficiencia asociada a la enfermedad.Los tratamientos antirretroviales son capaces de disminuir de forma marcada la replicaci\u00f3n vial y conducen a un incremento de linfocitos t cd4, sin embargo no consiguen recuaperarlas respuestas vih-espec\u00edficas ni consiguen erradicar el virus.Por ello seha centrado el inter\u00e9s en el sistema inmune del paciente como posible alternativa para erradicar el virus o al menos evitar la progresi\u00f3n de la enfermedad.El timo , como \u00f3rgano responsable de la repoblaci\u00f3n de los linfocitos t, podr\u00eda juagar un papel clave en esta recuperaci\u00f3n o reconstituci\u00f3n del sistema inmunol\u00f3gico.Por ello se estudi\u00f3 en ni\u00f3s, los cuales conservan la funcionalidad del timo, la reconstruci\u00f3n inmune y su posible beneficio en el contro l de la infecci\u00f3n por el vih.  los resultados demuestran el efecto inhibitorio del vih sobre la funci\u00f3n t\u00edmica y el papel clave que juega el timo en el mantenimiento dela poblaci\u00f3n cd4 en ni\u00f1\u00f3s infectados.La disminuci\u00f3n de carga viral tras la terapia antirretrovial conduce a una repoblaci\u00f3n  de linfocitos t cd4 que tienen mayotitariamente origen t\u00edmico y  la il-7 parece estar implicada en el mecanismo de homeostasis que activar\u00eda la producci\u00f3n t\u00edmica de estas c\u00e9lulas cd4.Esta repoblaci\u00f3n t\u00edmica permitir\u00e1 reconstruir el repertorio de especificidades de esta poblaci\u00f3n y se asociar\u00eda con la preservaci\u00f3n de distintos par\u00e1metros inmunol\u00f3gicos.La repoblaci\u00f3n t\u00edmica de linfocitos t cd4 observada en ni\u00f1os, se asoci\u00f3n con una preservaci\u00f3n de linfocitos memoria vih-espec\u00edficos que podr\u00edan conferir inmunidad protectivaa frente al vih.Estos resultados permiten un mejor entendimiento de la infecci\u00f3n por vih en ni\u00f1\u00f3s y apoyan el uso de estrategias encamiandas a mejorar la funci\u00f3n t\u00edmica como herramienta para alcanzar la reconstruci\u00f3n inmuni y el contr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recuperaci\u00f3n del sistema inmulolog\u00edco en ni\u00f1os infectados por el vih-1 efectos de la terapia antirretroviral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recuperaci\u00f3n del sistema inmulolog\u00edco en ni\u00f1os infectados por el vih-1 efectos de la terapia antirretroviral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Correa Rocha <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Angeles Mu\u00f1oz Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Nogales espert <\/li>\n<li>giuseppe Pantaleo (vocal)<\/li>\n<li>Manuel Fresno escudero (vocal)<\/li>\n<li>Manuel Leal noval (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Correa Rocha La principal consecuencisa de la infecci\u00f3n por el vih es una marcada depleci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[7781,150632,30047,22625,42307,150631],"class_list":["post-68617","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-angel-nogales-espert","tag-giuseppe-pantaleo","tag-m-angeles-munoz-fernandez","tag-manuel-fresno-escudero","tag-manuel-leal-noval","tag-rafael-correa-rocha"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68617"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68617\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}