{"id":68623,"date":"2018-03-09T23:12:50","date_gmt":"2018-03-09T23:12:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-del-sistema-del-oxido-nitrico-y-el-receptor-dopaminergico-d4-sobre-el-sueno-de-ratas\/"},"modified":"2018-03-09T23:12:50","modified_gmt":"2018-03-09T23:12:50","slug":"estudio-de-la-interaccion-del-sistema-del-oxido-nitrico-y-el-receptor-dopaminergico-d4-sobre-el-sueno-de-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/estudio-de-la-interaccion-del-sistema-del-oxido-nitrico-y-el-receptor-dopaminergico-d4-sobre-el-sueno-de-ratas\/","title":{"rendered":"Estudio de la interaccion del sistema del oxido nitrico y el receptor dopaminergico d4 sobre el sue\u00f1o de ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Cavas Toledo <\/strong><\/h2>\n<p>El estudio de la neurobiolog\u00eda del sue\u00f1o intenta conocer los procesos neurofisiol\u00f3gicos, neuroanat\u00f3micos y neuroqu\u00edmicos que originan y mantienen este estado. El \u00f3xido n\u00edtrico es un gas soluble, con potencial neurot\u00f3xico muy elevado, y con un mecanismo de acci\u00f3n muy diverso, que act\u00faa como sustancia neuromoduladora en el sistema nervioso. Varias l\u00edneas de investigaci\u00f3n han puesto de manifiesto que el \u00f3xido n\u00edtrico, los resultados han sido explicados por la interacci\u00f3n de esta sustancia con otros sistemas de neurotransmisi\u00f3n. Entre los sistemas con los que interact\u00faa el \u00f3xido n\u00edtrico se encuentra el sistema dopamin\u00e9rgico, de modo que el gas parece facilitar la transmisi\u00f3n dopamin\u00e9rgica. La implicaci\u00f3n de la dopamina en el sue\u00f1o es tambi\u00e9n controvertida. Mientras los receptores d1 y d2 intervienen en procesos de vigilia,parece que el receptor d4. En esta tesis doctoral se estudia: el papel del \u00f3xido n\u00edtrico producido por la \u00f3xido n\u00edtrico sintasa neuronal en el sue\u00f1o, utilizando una sustancia muy selectiva y potente para inhibir la enzima; el papel del receptor d4 dopamin\u00e9rgico en el sue\u00f1o mediante la administraci\u00f3n de un f\u00e1rmaco antagonista selectivo de este receptor, y una posible interacci\u00f3n entre el \u00f3xido n\u00edtrico y la transmisi\u00f3n dopamin\u00e9rgica mediada por el receptor d4 dopamin\u00e9rgico en la regulaci\u00f3n del sue\u00f1o.Los resultados indican que la inhibici\u00f3n del \u00f3xido n\u00edtrico disminuye el sue\u00f1o profundo, incrementando la vigilia. Se discuten los mecanismos neurobiol\u00f3gicos responsables de este efecto, que parecen relacionados con el prosenc\u00e9falo basal, la regi\u00f3n parabraquial del puente y el t\u00e1lamo. El antagonismo del receptor d4 produce un incremento de la vigilia tranquila y una disminuci\u00f3n de la vigilia activa tras la administraci\u00f3n de dosis medias del f\u00e1rmaco. Dosis superiores disminuyen el sue\u00f1o de ondas lentas, ligero y profundo y el n\u00famero de episodios desue\u00f1o parad\u00f3jico. El receptor d4<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interaccion del sistema del oxido nitrico y el receptor dopaminergico d4 sobre el sue\u00f1o de ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interaccion del sistema del oxido nitrico y el receptor dopaminergico d4 sobre el sue\u00f1o de ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Cavas Toledo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Navarro Humanes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amadeo Puerto salgado <\/li>\n<li> Narvaez bueno Jos\u00e9 angel (vocal)<\/li>\n<li>angel Nu\u00f1ez molina (vocal)<\/li>\n<li>gualberto Buena casal (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Cavas Toledo El estudio de la neurobiolog\u00eda del sue\u00f1o intenta conocer los procesos neurofisiol\u00f3gicos, neuroanat\u00f3micos y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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