{"id":68635,"date":"2018-03-09T23:13:01","date_gmt":"2018-03-09T23:13:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-protea%c2%adnas-de-la-superficie-celular-de-candida-albicans\/"},"modified":"2018-03-09T23:13:01","modified_gmt":"2018-03-09T23:13:01","slug":"estudio-de-protea%c2%adnas-de-la-superficie-celular-de-candida-albicans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-protea%c2%adnas-de-la-superficie-celular-de-candida-albicans\/","title":{"rendered":"Estudio de prote\u00ednas de la superficie celular de candida albicans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Mart\u00ednez P\u00e9rez-romero <\/strong><\/h2>\n<p>La pared celular es una diana de elecci\u00f3n para el desarrollo de f\u00e1rmacos antif\u00fangicos. Un 35% del peso seco de la pared celular de c.Albicans est\u00e1 constituido por las manoprote\u00ednas. Entre las prote\u00ednas unidas covalentemente a la pared celular podemos encontrar dos tipos: las prote\u00ednas gpi (glucosilfosfatidilinositol) y las prote\u00ednas pir (prote\u00ednas con repeticiones internas).  una b\u00fasqueda de hom\u00f3logos de prote\u00ednas de la familia pir de saccharomyces cerevisiae en una base de datos de c.Albicans mostr\u00f3 la existencia de un \u00fanico gen con caracter\u00edsticas t\u00edpicas de los miembros de esa familia. El gen capir1 de c.Albicans presenta dos alelos de desigual tama\u00f1o, que se diferencian en el n\u00famero de repeticiones internas en su secuencia.  el marcaje de la prote\u00edna con el epitopo v5 muestra que capir1 se encuentra unida covalentemente a la pared celular de c.Albicans mediante enlace sensible al \u00e1lcali y es secretada al medio durante su cultivo. Los mutantes heterocig\u00f3ticos en cada uno de los alelos mostraron un fenotipo id\u00e9ntico, sin embargo ambos mutantes resultaron ser fenot\u00edpicamente diferentes a su cepa parental. los mutantes presentaron una velocidad de crecimiento m\u00e1s lenta y morfolog\u00eda alterada con respecto a c\u00e9lulas de la cepa parental cai4 as\u00ed como una mayor sensibilidad a sustancias que afectan el correcto ensamblaje de los componentes de la pared celular (calcofluor white y rojo congo); adem\u00e1s mostraron una disminuci\u00f3n en la filamentaci\u00f3n en medio s\u00f3lido. La imposibilidad de obtener el mutante homocig\u00f3tico, as\u00ed como el elevado efecto fenot\u00edpico de la interrupci\u00f3n de un solo alelo abre la posibilidad de que capir1 sea un gen esencial en c.Albicans.  adem\u00e1s, se ha estudiado otro gen de c.Albicans, caplp1, que presenta cierta homolog\u00eda con miembros de la familia pir pero no codifica una prote\u00edna pir t\u00edpica. Su interrupci\u00f3n produce una mayor sensibilidad a rojo congo y calcofluor white.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de prote\u00ednas de la superficie celular de candida albicans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de prote\u00ednas de la superficie celular de candida albicans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Mart\u00ednez P\u00e9rez-romero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Sentandreu Ramon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 pedro Martinez garcia <\/li>\n<li>concepcion Gil garcia (vocal)<\/li>\n<li> Castillo agudo lucas del (vocal)<\/li>\n<li> Sanz bigorra pascual felipe (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Mart\u00ednez P\u00e9rez-romero La pared celular es una diana de elecci\u00f3n para el desarrollo de f\u00e1rmacos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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