{"id":68645,"date":"2018-03-09T23:13:01","date_gmt":"2018-03-09T23:13:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-predictivos-de-la-hematotoxicidad-de-nuevos-farmacos-antitumorales-de-origen-marino\/"},"modified":"2018-03-09T23:13:01","modified_gmt":"2018-03-09T23:13:01","slug":"estudios-predictivos-de-la-hematotoxicidad-de-nuevos-farmacos-antitumorales-de-origen-marino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudios-predictivos-de-la-hematotoxicidad-de-nuevos-farmacos-antitumorales-de-origen-marino\/","title":{"rendered":"Estudios predictivos de la hematotoxicidad de nuevos f\u00e1rmacos antitumorales de origen marino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Garc\u00eda G\u00f3mez <\/strong><\/h2>\n<p>El sistema hematopoy\u00e9tico es un tejido organizado jer\u00e1rquicamente en el que a partir de una peque\u00f1a poblaci\u00f3n de c\u00e9lulas madre se produce el resto de poblaciones celulares que componen dicho sistema. Estas c\u00e9lulas, por proliferaci\u00f3n, van generando poblaciones celulares amplificadas y diferenciadas que, por maduraci\u00f3n, temina originando los tipos celulares sangu\u00edneos funcionales. todo este proceso hace que el sistema hematopoy\u00e9tico est\u00e9 constituido por una gran heterogeneidad celular. Cl\u00e1sicamente se consideran tres compartimentos, c\u00e9lulas madre, precursores comprometidos y c\u00e9lulas maduras.  la toxicidad en el tejido hematopoy\u00e9tico se puede traducir en dos tipos de efectos cuando los compuestos antitumorales son administrados in vivo. por una parte, la aparici\u00f3n de problemas a corto plazo como son neutropenias y trombocitopenias m\u00e1s o menos agudas en funci\u00f3n de la toxicidad producida en los progenitores hematopoy\u00e9ticos comprometidos. Por otro lado, una vez superadas dichas citopenias, podr\u00edan presentarse problemas graves a largo plazo si la poblaci\u00f3n de c\u00e9lulas madre tambi\u00e9n se ve afectada.  el objetivo del presente trabajo es caracterizar el efecto de tres compuestos antitumorales de origen marino (trabectedin, aplidin(r) y kahalalide f) en el tejido hematopoy\u00e9tico. Se ha estudiado la toxicidad en progenitores comprometidos hematopoy\u00e9ticos, de origen humano y murino, con ensayos clonog\u00e9nicos in vitro. Los precursores comprometidos a estudiar con las unidades de colonias granulomacrof\u00e1gicas (cfu-gm) que dan lugar a los monocitos y neutr\u00f3filos, las unidades formadoras de colonias eritroides (bfu-e) que dan lugar a la l\u00ednea eritroide, las unidades formadoras de colonias megacarioc\u00edticas (cfu-meg) precursores de las pla quetas y unos progenitores m\u00e1s primitivos denominados unidades formadoras de colonias mixtas (cfu-mix).  adem\u00e1s del estudio de la toxicidad en precursores hematopoy\u00e9ticos, se ha estudiado la t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios predictivos de la hematotoxicidad de nuevos f\u00e1rmacos antitumorales de origen marino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios predictivos de la hematotoxicidad de nuevos f\u00e1rmacos antitumorales de origen marino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Garc\u00eda G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Beatriz Albella Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gos\u00e1lvez berenguer Jos\u00e9 Jaime <\/li>\n<li>Jos\u00e9 vicente Castells ripoll (vocal)<\/li>\n<li>carmen Gonz\u00e1lez mart\u00edn (vocal)<\/li>\n<li>Jos\u00e9 m. Jimeno do\u00f1aque (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Garc\u00eda G\u00f3mez El sistema hematopoy\u00e9tico es un tejido organizado jer\u00e1rquicamente en el que a partir de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[17435,150676,44392,150677,10754,3723],"class_list":["post-68645","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-beatriz-albella-rodriguez","tag-carmen-gonzalez-martin","tag-gosalvez-berenguer-jose-jaime","tag-jose-m-jimeno-donaque","tag-jose-vicente-castells-ripoll","tag-susana-garcia-gomez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68645"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68645\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}