{"id":68734,"date":"2018-03-09T23:13:08","date_gmt":"2018-03-09T23:13:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-transduccion-de-senal-implicados-en-el-efecto-de-los-inhibidores-selectivos-de-cox-2-en-el-tratamiento-de-cancer-de-colon\/"},"modified":"2018-03-09T23:13:08","modified_gmt":"2018-03-09T23:13:08","slug":"mecanismos-de-transduccion-de-senal-implicados-en-el-efecto-de-los-inhibidores-selectivos-de-cox-2-en-el-tratamiento-de-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/mecanismos-de-transduccion-de-senal-implicados-en-el-efecto-de-los-inhibidores-selectivos-de-cox-2-en-el-tratamiento-de-cancer-de-colon\/","title":{"rendered":"Mecanismos de transducci\u00f3n de se\u00f1al implicados en el efecto de los inhibidores selectivos de cox-2 en el tratamiento de c\u00e1ncer de col\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isolda Casanova Rigat <\/strong><\/h2>\n<p>Los antiinflamatorios no esteroideos (aines) son f\u00e1rmacos que act\u00faan inhibiendo la actividad de las dos isoformas del enzima cilooxigenasa (cox-1 y cox-2) y se usan mayoritariamente en cl\u00ednica para el tratamiento del dolor y la inflamaci\u00f3n, pero tambi\u00e9n se ha descrito su acci\u00f3n como antitumorales. su principal inconveniente es la aparici\u00f3n de efectos secundarios, principalmente como consecuencia de la inhibici\u00f3n de cox-1. Por este motivo, se han desarrollado nuevos compuestos que inhiben selectivamente cox-2 de manera que mantienen el efecto terap\u00e9utico, consecuencia de la inhibici\u00f3n de cox-2, y reducen los efectos secundarios. El mecanismo de acci\u00f3n de estos compuestos como antitumorales es actualmente objeto de mucha controversia y no est\u00e1 claro si act\u00faan a trav\u00e9s de la inhibici\u00f3n de cox-2 o bien por un mecanismo indpendiente.  en esta tesis doctoral, se ha estudiado el mecanismo de accion antitumoral de diversos compuestos inhibidores selectivos de cox-2, en c\u00e9lulas de carcinoma de colon humano, determinando que la capacidad inhibidora del cox-2 de los compuestos es independiente de su efecto antitumoral. Por otro lado, se han analizado las v\u00edas de transducci\u00f3n de se\u00f1al implicadas en el efecto antitumoral in vitro e in vivo del celecoxib, un inhibidor selectivo de cox-2 usado actualmente en cl\u00ednica. El celecoxib induce apoptosis por la v\u00eda mitocondrial en c\u00e9lulas de carinoma de colon. Adem\u00e1s, altera las prote\u00ednas que forman las adhesiones focales induciendo la p\u00e9rdida de anclaje de las c\u00e9lulas y, en consecuencia, la muerte de las c\u00e9lulas por anoikis. El celecoxib es tambi\u00e9n efectivo in vivo, en un modelo de xenotrasplante en ratones at\u00edmicos. El lugar de implantaci\u00f3n tumoral no influye en el efecto antitumoral del f\u00e1rmaco pero s\u00ed en su mecanismo de acci\u00f3n. Cuando se implantan los tumores, derivados de un carcinoma de colon humano, en el subcutis del animal, el celecoxib induce necrosis. En cambio, si los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de transducci\u00f3n de se\u00f1al implicados en el efecto de los inhibidores selectivos de cox-2 en el tratamiento de c\u00e1ncer de col\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de transducci\u00f3n de se\u00f1al implicados en el efecto de los inhibidores selectivos de cox-2 en el tratamiento de c\u00e1ncer de col\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isolda Casanova Rigat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Mangues Bafalluy<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mar\u00ed\u00a7al Pastor anglada <\/li>\n<li>gabriel Capella munar (vocal)<\/li>\n<li>Marta Cascante serratosa (vocal)<\/li>\n<li>agust\u00ed Barnadas molins (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isolda Casanova Rigat Los antiinflamatorios no esteroideos (aines) son f\u00e1rmacos que act\u00faan inhibiendo la actividad de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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