{"id":68751,"date":"2018-03-09T23:13:08","date_gmt":"2018-03-09T23:13:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-proceso-de-recaptacion-de-anandamida-mediante-la-sa%c2%adntesis-de-inhibidores-y-evaluacion-de-su-aplicabilidad-terapeutica\/"},"modified":"2018-03-09T23:13:08","modified_gmt":"2018-03-09T23:13:08","slug":"estudio-del-proceso-de-recaptacion-de-anandamida-mediante-la-sa%c2%adntesis-de-inhibidores-y-evaluacion-de-su-aplicabilidad-terapeutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-proceso-de-recaptacion-de-anandamida-mediante-la-sa%c2%adntesis-de-inhibidores-y-evaluacion-de-su-aplicabilidad-terapeutica\/","title":{"rendered":"Estudio del proceso de recaptaci\u00f3n de anandamida mediante la s\u00edntesis de inhibidores y evaluaci\u00f3n de su aplicabilidad terap\u00e9utica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Ortega Guti\u00e9rrez <\/strong><\/h2>\n<p>El presente trabajo de tesis doctoral ha consistido en el dise\u00f1o , s\u00edntesis y desarrollo de nuevos inhibidores de la recaptaci\u00f3n de anandamida derivados de \u00e1cidos grasos.La mayor\u00eda de los compuestos sintetizados ha mostrado una elevada afinidadd (ci50=25-0,8um)para inhibier el transporte de anandamida, resultado asimismo selectivos por el resto de prote\u00ednas qu constituyen el sistema cannabinoide end\u00f3geno (receptores cb1 y cb2 y la enzima faah)y por los receptores de vanilloides vr1.El an\u00e1lisis cualitativo de relaci\u00f3n estructura-afinidad ha permitido profundizar en los requerimientos estructurales \u00f3ptimos para la inhibici\u00f3n de la recaptaci\u00f3n de anandamida.Este estudio ha culminado en la identificaci\u00f3n del ucm707 como el inhibidor m\u00e1s potente (ci50=0,8 um)y selectivo hasta la fecha.Este prometedor perfil in vitro el ucm707 una valiosa herramienta para estudiar el proceso de recaptaci\u00f3n de anandamida y evaluar su aplicabilidad terap\u00e9utica.Mediante el empleo del ucm707 en cultivos neuronales obtenidos a partir de ratones faah-\/- y faah+\/+,se ha estudiado la contribuci\u00f3n de la enzima faah al proceso de recaptaci\u00f3n de anandamida.Este proceso es un fen\u00f3meno complejo en el que intervienen distintas prote\u00ednas y tambi\u00e9n , aunque en menor extensi\u00f3n , la difusi\u00f3n simple a trav\u00e9s de la membrana.Dentro del componente proteico, destaca la existencia de una entidad proteica sensible al ucm707 que es responsable de aproximadamente el 50% de la internalizaci\u00f3n de anandamida y podr\u00eda corresponder a una prote\u00edna citos\u00f3lica transportadora de l\u00edpidos.  respecto a la aplicabilidad terap\u00e9utica del ucm707, se ha comprobado que el tratamiento con este compuesto produce importantes beneficios en el modelo de esclerosis m\u00faltiple inducido pro infecci\u00f3n por el virus de theiler, mejorando significativamente las disfunciones motoras asociadas al proceso de la enfermedad.El ucm707 provoca una disminuci\u00f3n en la reactividad microglial , e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del proceso de recaptaci\u00f3n de anandamida mediante la s\u00edntesis de inhibidores y evaluaci\u00f3n de su aplicabilidad terap\u00e9utica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del proceso de recaptaci\u00f3n de anandamida mediante la s\u00edntesis de inhibidores y evaluaci\u00f3n de su aplicabilidad terap\u00e9utica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Ortega Guti\u00e9rrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Luz Lopez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Seoane prado <\/li>\n<li>Manuel Guzman rastor (vocal)<\/li>\n<li>beat Lutz (vocal)<\/li>\n<li>carmen Gauza rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Ortega Guti\u00e9rrez El presente trabajo de tesis doctoral ha consistido en el dise\u00f1o , s\u00edntesis y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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