{"id":68886,"date":"2004-01-07T00:00:00","date_gmt":"2004-01-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-aparicion-y-desarrollo-de-tolerancia-a-la-morfina-en-un-modelo-de-inflamacion-monoarticular-en-raton\/"},"modified":"2004-01-07T00:00:00","modified_gmt":"2004-01-07T00:00:00","slug":"caracterizacion-de-la-aparicion-y-desarrollo-de-tolerancia-a-la-morfina-en-un-modelo-de-inflamacion-monoarticular-en-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-aparicion-y-desarrollo-de-tolerancia-a-la-morfina-en-un-modelo-de-inflamacion-monoarticular-en-raton\/","title":{"rendered":"Caracterizaci\u00f3n de la aparici\u00f3n y desarrollo de tolerancia a la morfina en un modelo de inflamaci\u00f3n monoarticular en rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> V\u00edctor Fern\u00e1ndez Due\u00f1as <\/strong><\/h2>\n<p>Los opioides se utilizan en el tratamiento del dolor osteoarticular cr\u00f3nico, pero se desconocen las caracter\u00edsticas de aparici\u00f3n de tolerancia a sus efectos durante estos procesos. Postulamos que la inflamaci\u00f3n puede alterar la aparici\u00f3n\/desarrollo de tolerancia opioide ya que se inducen cambios en la transmisi\u00f3n nocicpetiva y en la expresi\u00f3n de receptores opioides.  metodolog\u00eda  en un modelo de monoartritis producida por adyuvante de freud (cfa) en ratones control y tolerantes (con la implantaci\u00f3n de un comprimido s.C., de morfina), se evaluaron: peso corporal, di\u00e1metro de la articulaci\u00f3n, respuesta nociceptiva a est\u00edmulos t\u00e9rmicos (plantar test) y mec\u00e1nicos (randall y selitto, von frey), extravasaci\u00f3n de plasma y tr\u00e1nsito intestinal. Tambi\u00e9n se estudiaron los efectos de la administraci\u00f3n sist\u00e9mica de morfina y la reversi\u00f3n por naloxona y naloxona metiodada. Finalmente se estudi\u00f3 la expresi\u00f3n de receptores opioides u en tejidos perif\u00e9ricos (plantar, ganglios de la ra\u00edz dorsal y m\u00e9dula espinal) mediante western blot.  resultados  el cfa  indujo una inflamaci\u00f3n localizada, cuantificable entre las 4 horas y los 14 d\u00edas. El efecto anti-nociceptivo y anti-inflamatorio de la morfina fue significativamente mayor en presencia de inflamaci\u00f3n (x2), sin modificar el efecto anti-alod\u00ednico. La implantaci\u00f3n de un comprimido de morfina produjo una disminuci\u00f3n de la sensibilidad nociceptiva a los est\u00edmulos t\u00e9rmicos y mec\u00e1nicos. Induciendo tolerancia opioide a los efectos anti-nociceptivos y anti-inflamatorios de la morfina. Asimismo en presencia de inflamaci\u00f3n el desarrollo de tolerancia fue mayor. Los resultados de conducta obtenidos se relacionaron con los obtenidos a nivel molecular. La inflamaci\u00f3n perif\u00e9rica aument\u00f3 la expresi\u00f3n de receptores opioides, y en presencia de tolerancia a la morfina los resultados sugieron la no-funcionalidad de estos receptores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de la aparici\u00f3n y desarrollo de tolerancia a la morfina en un modelo de inflamaci\u00f3n monoarticular en rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de la aparici\u00f3n y desarrollo de tolerancia a la morfina en un modelo de inflamaci\u00f3n monoarticular en rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 V\u00edctor Fern\u00e1ndez Due\u00f1as <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Puig Riera De Con\u00edas Margarita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Luisa Laorden carrasco <\/li>\n<li>m. eulalia Planas  domingo (vocal)<\/li>\n<li>m.victoria Milan\u00e9s maquill\u00f3n (vocal)<\/li>\n<li>Javier Garz\u00f3n  ni\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de V\u00edctor Fern\u00e1ndez Due\u00f1as Los opioides se utilizan en el tratamiento del dolor osteoarticular cr\u00f3nico, pero se desconocen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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