{"id":68913,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/las-talasemias-en-la-baha%c2%ada-de-cadiz-estudio-de-la-lesion-molecular\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"las-talasemias-en-la-baha%c2%ada-de-cadiz-estudio-de-la-lesion-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cadiz\/las-talasemias-en-la-baha%c2%ada-de-cadiz-estudio-de-la-lesion-molecular\/","title":{"rendered":"Las talasemias en la bah\u00edade c\u00e1diz. estudio de la lesi\u00f3n molecular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen De Cos H\u00c1\u00b6hr <\/strong><\/h2>\n<p>Introducci\u00f3n  las talasemias son un grupo heterog\u00e9neo de anemias hemol\u00edticas hereditarias caracterizadas por la disminuci\u00f3n o ausencia de una o m\u00e1s cadenas  de globina. el programa de diagn\u00f3stico y control de talasemias y hemoglobinopat\u00edas en la bah\u00eda de c\u00e1diz ha permitido durante los \u00faltimos 25 a\u00f1os la detecci\u00f3n de portadores de talasemia, su estudio familiar, la realizaci\u00f3n de informaci\u00f3n y consejo gen\u00e9tico, el control y seguimiento de grupos de riesgo.  objetivos  1,- estudio de la homogeneidad de la poblaci\u00f3n eitroide como m\u00e9todo de escrutinio.  2,- estudio de la lesi\u00f3n molecular y su comportamiento cl\u00ednico-biol\u00f3gico.  3,- frecuencia g\u00e9nica de talasemias y lesiones moleculares.  4,- evoluci\u00f3n del equilibrio g\u00e9nico.  enfermos y m\u00e9todos  estudio poblacional en el \u00e1rea de c\u00e1diz-san fernando (226081 habitantes). realizaci\u00f3n del estudio en dos fases:  1,- fase de escrutinio, realizada a partir de 18422 hemogramas, que permitieron obtner los patrones de normalidad de las ecuaciones de england y mentzer, metabolismo del hierro y estudio del receptor soluble de transferina.  2,- fase de estudio propiamente dicho, realizada a partir de 11472 individuos, que permitieron el an\u00e1lisis de 69 beta talasemias, sobre las cuales se realiz\u00f3 el an\u00e1lisis de las alteraciones moleculares responsables del trastorno.  3,- a partir de los datos anteriores y de los obtenidos en a\u00f1os previos, valoramos el an\u00e1lisis del equilibrio fenot\u00edpico y g\u00e9nico, mediante la ley de hardy weinberg.  resultados  1,- fase de escrutinio. A partir de los 18422 hemogramas antedichos, fueron detectados 299 individuos con microcitosis, de los cuales 173 correspond\u00edan a ferropenias y el resto a beta-talasemias. Con un punto de corte en 0, la ecuaci\u00f3n de england present\u00f3 un valor predictivo positivo para el diagn\u00f3stico de beta-talasemia de 0,942, y un valor predictivo negativo de 0,826. Con un punto de corte en 13, la ecuaci\u00f3n de m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Las talasemias en la bah\u00edade c\u00e1diz. estudio de la lesi\u00f3n molecular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Las talasemias en la bah\u00edade c\u00e1diz. estudio de la lesi\u00f3n molecular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen De Cos H\u00c1\u00b6hr <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gir\u00f3n Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda De castro romero <\/li>\n<li>alipio Mangas rojas (vocal)<\/li>\n<li>Jes\u00fas Millan nu\u00f1ez cortes (vocal)<\/li>\n<li> Rodriguez fern\u00e1ndez Juan  m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen De Cos H\u00c1\u00b6hr Introducci\u00f3n las talasemias son un grupo heterog\u00e9neo de anemias hemol\u00edticas hereditarias caracterizadas por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506],"tags":[1882,151131,1552,10865,1822,46490],"class_list":["post-68913","post","type-post","status-publish","format-standard","hentry","category-cadiz","tag-alipio-mangas-rojas","tag-carmen-de-cos-hahr","tag-jesus-millan-nunez-cortes","tag-jose-antonio-giron-gonzalez","tag-jose-maria-de-castro-romero","tag-rodriguez-fernandez-juan-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68913"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68913\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}