{"id":68914,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-de-mutagenesis-y-reparacion-de-adn-en-plantas-identificacion-y-caracterizacion-de-los-genes-atnth1-atogg1-y-atpolk-de-arabidopsis-thaliana\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"mecanismos-moleculares-de-mutagenesis-y-reparacion-de-adn-en-plantas-identificacion-y-caracterizacion-de-los-genes-atnth1-atogg1-y-atpolk-de-arabidopsis-thaliana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/mecanismos-moleculares-de-mutagenesis-y-reparacion-de-adn-en-plantas-identificacion-y-caracterizacion-de-los-genes-atnth1-atogg1-y-atpolk-de-arabidopsis-thaliana\/","title":{"rendered":"Mecanismos moleculares de mutag\u00e9nesis y reparaci\u00f3n de adn en plantas: identificaci\u00f3n y caracterizaci\u00f3n de los genes atnth1, atogg1 y atpolk de arabidopsis thaliana"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Ortiz Mar\u00eda  Victoria <\/strong><\/h2>\n<p>Los mecanismos de reparaci\u00f3n del da\u00f1o en el adn y su tolerancia han sido estudiados intensivamente en microorganismos y animales, pero el conocimiento sobre ambos procesos en plantas es muy limitado. El objetivo de esta tesis ha sido identificar y caracterizar genes de arabidopsis thaliana implicados en la reparaci\u00f3n de lesiones en el adn, as\u00ed como de genes relacionados con mecanismos de tolerancia al da\u00f1o.  los resultados obtenidos indican que arabidopsis thaliana posee un hom\u00f3logo estructural y funcional de la prote\u00edna nth de escherichia coli, al que se ha denominado atnth1. Atnth1 es una adn glicosilasa\/liasa que cataliza la escisi\u00f3n de pirimidinas oxidadas (tales como timinglicol y urea) del adn. El gen atnth1 consta de 11 exones y 10 intrones, y se expresa en un amplio rango de tejidos de la planta. arabidopsis thaliana posee adem\u00e1s un hom\u00f3logo estructural y funcional de la prote\u00edna ogg1 de saccharomyces cerevisiae, al que se ha denominado atogg1. la purificaci\u00f3n y caracterizaci\u00f3n enzim\u00e1tica de la prote\u00edna atogg1 ha demostrado que se trata de una 8-oxoguanina adn glicosilasa\/liasa que act\u00faa preferentemente sobre pares 8-oxog:c in vitro, y que es capaz de contrarrestar in vivo el efecto mutag\u00e9nico de la 8-oxog.  por otra parte, arabidopsis thaliana posee una prote\u00edna perteneciente a la familia y de adn polimerasas, que se ha denominado atpolk. Atpolk muestra la arquitectura t\u00edpica de una prote\u00edna de la familia y, con un dominio polimerasa amino-terminal que contiene cinco regiones altamente conservadas y un dominio carboxi-terminal menos conservado. La actividad enzim\u00e1tica de una forma truncada de la prote\u00edna demuestra que el dominio carboxilo de atpolk limita su actividad polimerasa y su procesividad, pero aumenta su especificidad a la hora de incorporar el nucle\u00f3tido correcto. La expresi\u00f3n de atpolk parece estar regulada a distintos niveles. As\u00ed, el arnm del gen atpolk sufre un procesamiento alternativo q<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares de mutag\u00e9nesis y reparaci\u00f3n de adn en plantas: identificaci\u00f3n y caracterizaci\u00f3n de los genes atnth1, atogg1 y atpolk de arabidopsis thaliana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares de mutag\u00e9nesis y reparaci\u00f3n de adn en plantas: identificaci\u00f3n y caracterizaci\u00f3n de los genes atnth1, atogg1 y atpolk de arabidopsis thaliana <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Ortiz Mar\u00eda  Victoria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Roldan Arjona M. Teresa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Miguel angel comendador garcia <\/li>\n<li>bustamante Joaquin pi\u00f1ero (vocal)<\/li>\n<li>Emilio Fernandez reyes (vocal)<\/li>\n<li> Maria angeles de la torre ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Ortiz Mar\u00eda Victoria Los mecanismos de reparaci\u00f3n del da\u00f1o en el adn y su tolerancia han [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973],"tags":[151135,1981,151132,131582,151134,151133],"class_list":["post-68914","post","type-post","status-publish","format-standard","hentry","category-cordoba","tag-bustamante-joaquin-pinero","tag-emilio-fernandez-reyes","tag-garcia-ortiz-maria-victoria","tag-maria-angeles-de-la-torre-ruiz","tag-miguel-angel-comendador-garcia","tag-roldan-arjona-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68914"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68914\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}