{"id":68926,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-adaptativa-y-patogenica-en-neospora-caninum\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"variabilidad-adaptativa-y-patogenica-en-neospora-caninum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-adaptativa-y-patogenica-en-neospora-caninum\/","title":{"rendered":"Variabilidad adaptativa y patog\u00e9nica en neospora caninum"},"content":{"rendered":"

Tesis doctoral de P\u00e9rez Zaballos Francisco Jose <\/strong><\/h2>\n

En el primer experimento de esta tesis doctoral, se ha comporado la adaptaci\u00f3n de tres aislados de n.Caninum (nc-1, nc-sweb1 y nc-liverpool) a nuevos ambientes, cultivando al par\u00e1sito en una nueva l\u00ednea celular, usando un modelo experimental similar al propuesto por travisano et al. (Science, 267:87-90, 1995), para estudiar el papel de la adaptaci\u00f3n en las poblaciones de bacterias en el laboratorio. En nuestro experimento, el par\u00e1metro maltusiano de fitness se determin\u00f3 en casa aislado, midiendo la multiplicaci\u00f3n asexual, en 10 r\u00e9plicas diferentes, de taquizo\u00edtos de cada uno de los aislados antes y despu\u00e9s de realizar 38 pases en la l\u00ednea celular marc-145. Los resultados de la prueba de evoluci\u00f3n mostraron un incremento significativo de la media (m250 mayor m0) para los tres aislados de n.Caninum (p menor 0,001). Los resultados de la prueba de diversidad gen\u00e9tica revelaron diferencias significativas del fitness entre los tres cultivos clonales de n.Caninum en t=0 y t=250. en contraste con las cl\u00e1sicas predicciones del trinquete de muller, los valores del fitness obtenidos para los tres aislados mostraron r\u00e1pidos cambios adaptativos. Todo ello, apoya la idea de que la propagaci\u00f3n asexual de n.Caninum de modo vertical por la v\u00eda trasnplacentaria en la naturaleza, u otras alternativas de transmisi\u00f3n horizonal. Todas las evidencias de nuestro estudio confirman que la estructura de poblaci\u00f3n clonal debe ser mantenida como posible base de las poblaciones de neospora. en el segundo experimento, los objetivos fueron comparar la patogenicidad, durante las fases aguda y cr\u00f3nica de la neosporosis, de tres aislados de n.Caninum en un modelo de rat\u00f3n, antes (t=0) y despu\u00e9s (t=250) del paso del par\u00e1sito por el cultivo celular durante aproximadamente 250 generaciones. para ello, 15 ratones hembra balb\/c fueron inoculados con 5×10 6 taquizo\u00edtos de cada aislado y pase (t=0 y t=250) por cultivo celular o solo con pbs (nueve grupos d<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abVariabilidad adaptativa y patog\u00e9nica en neospora caninum<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad adaptativa y patog\u00e9nica en neospora caninum <\/li>\n
  • Autor:<\/strong>\u00a0 P\u00e9rez Zaballos Francisco Jose <\/li>\n
  • Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Luis Miguel Ortega Mora<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Lopez rodas m. victoria <\/li>\n
        • Pereira bueno Juan a Mar\u00eda (vocal)<\/li>\n
        • vicente Goyanes villaescusa (vocal)<\/li>\n
        • gorka Aduriz rekalde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de P\u00e9rez Zaballos Francisco Jose En el primer experimento de esta tesis doctoral, se ha comporado la adaptaci\u00f3n […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[39452,23638,39453,151156,151155,18632],"class_list":["post-68926","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-gorka-aduriz-rekalde","tag-lopez-rodas-m-victoria","tag-luis-miguel-ortega-mora","tag-pereira-bueno-juan-a-maria","tag-perez-zaballos-francisco-jose","tag-vicente-goyanes-villaescusa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68926"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68926\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}