{"id":68956,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-condicionantes-de-la-vulnerabilidad-de-las-neuronas-dopaminergicas-mesencefalicas\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"factores-condicionantes-de-la-vulnerabilidad-de-las-neuronas-dopaminergicas-mesencefalicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/factores-condicionantes-de-la-vulnerabilidad-de-las-neuronas-dopaminergicas-mesencefalicas\/","title":{"rendered":"Factores condicionantes de la vulnerabilidad de las neuronas dopaminergicas mesencefalicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Barroso Chinea Pedro Javier <\/strong><\/h2>\n<p>La enfermedad de parkinson (ep) es un trastorno neurodegenerativo, cr\u00f3nico y progresivo, que afecta al 1% de la poblaci\u00f3n por encima de los 65 a\u00f1os, lo que la convierte en un verdadero problema sanitario, social y econ\u00f3mico.  cl\u00ednicamente, se caracteriza por temblor de reposo, rigidez y acinesia y desde un punto de vista anat\u00f3mico-patol\u00f3gico por la degeneraci\u00f3n de las neuronas deopamin\u00e9rgicas mesencef\u00e1licas. Aunque el estr\u00e9s oxidativo y el deficit mitocondrial han sido implicados en su patogenia, actualmente se desconoce la causa y los mecanismos desencadenantes de la degeneraci\u00f3n neuronal. En este trabajo nos hemos centrado en los siguientes objetivos:  1,- dise\u00f1o y optimizaci\u00f3n de un modelo animal (rata) de ep que emule los s\u00edntomas cl\u00ednicos y el patr\u00f3n topogr\u00e1fico de degeneraci\u00f3n, mediante la inyecci\u00f3n intracerebroventricular (i.C.V; tercer ventr\u00edculo) de 6-hidroxidopamina (6-ohda) y la utilizaci\u00f3n de t\u00e9cnicas morfol\u00f3gicas y conductuales.  2,- utilizando este modelo, determinar el papel de determinados factores del perf\u00edl neuroqu\u00edmico: transportadores de dopamina (dat y vmat-2), prote\u00ednas fijadoras de calcio intracelular (calretinia y calbindina), tama\u00f1o celular y coexpresi\u00f3n de gad en la vulnerabilidad diferencial de las neuronas dopamin\u00e9rgicas a la degeneraci\u00f3n, mediante t\u00e9cnicas morfol\u00f3gicas y de biolog\u00eda molecular en tejido cerebral de rata, mono y humano.  3,- estudiar a nivel electrofisiol\u00f3gico, neuroqu\u00edmico y hodol\u00f3gico la implicaci\u00f3n del n\u00facleo mesencef\u00e1lico profundo en los ganglios basales y en el control motor.  4,- estudiar, a nivel electrofisiol\u00f3gico, morfol\u00f3gico y bioqu\u00edmico, la respuesta de diferentes poblaciones neuronales mesencef\u00e1licas a la lesi\u00f3n de la v\u00eda dopamin\u00e9rgica mesoestriatal.  nuestros resultados revelan que:  1,- la inyecci\u00f3n i.C.V., Induce una degeneraci\u00f3n bilateral, sim\u00e9trica y dosis-dependiente con un patr\u00f3n conductual y topogr\u00e1fico de degenerac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores condicionantes de la vulnerabilidad de las neuronas dopaminergicas mesencefalicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores condicionantes de la vulnerabilidad de las neuronas dopaminergicas mesencefalicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Barroso Chinea Pedro Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Rodriguez Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Feria rodriguez <\/li>\n<li>Jos\u00e9 Luis Lanciego perez (vocal)<\/li>\n<li>Jos\u00e9 a. Obeso inchausti (vocal)<\/li>\n<li> P\u00e9rez delgado Mar\u00eda  del mar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Barroso Chinea Pedro Javier La enfermedad de parkinson (ep) es un trastorno neurodegenerativo, cr\u00f3nico y progresivo, que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9915],"tags":[151206,9920,9695,9924,10380,151207],"class_list":["post-68956","post","type-post","status-publish","format-standard","hentry","category-la-laguna","tag-barroso-chinea-pedro-javier","tag-jose-a-obeso-inchausti","tag-jose-luis-lanciego-perez","tag-manuel-feria-rodriguez","tag-manuel-rodriguez-diaz","tag-perez-delgado-maria-del-mar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=68956"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/68956\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=68956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=68956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=68956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}