{"id":68970,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacogenetica-de-los-enzimas-metabolicos-el-ejemplo-de-la-tiopurina-s-metiltransferasa-tpmt-y-el-metabolismo-de-azatioprina-en-las-enfermedades-inflamatorias-cronicas\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"farmacogenetica-de-los-enzimas-metabolicos-el-ejemplo-de-la-tiopurina-s-metiltransferasa-tpmt-y-el-metabolismo-de-azatioprina-en-las-enfermedades-inflamatorias-cronicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacogenetica-de-los-enzimas-metabolicos-el-ejemplo-de-la-tiopurina-s-metiltransferasa-tpmt-y-el-metabolismo-de-azatioprina-en-las-enfermedades-inflamatorias-cronicas\/","title":{"rendered":"Farmacogenetica de los enzimas metabolicos: el ejemplo de la tiopurina s-metiltransferasa (tpmt) y el metabolismo de azatioprina en las enfermedades inflamatorias cronicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hector Corominas Mac\u00edas <\/strong><\/h2>\n<p>Objetivo  1,- analizar los polimorfismos de tiopurina s- metiltransfersa (tpmt).  2,- describir las mutaciones de tpmt en artritis reumatoide (ar) y la enfermedad inflamatoria intestinal (eii).  3,- estudiar el gen de tpmt en diferente origen \u00e9tnico.  4,- reportar individuos portadores heterocigotos con baja actividad enzim\u00e1tica (tpmt hl).  5,- demostrar si el polimorfismo gen\u00e9tico del tpmt justifica la retirada de azatioprina.  material y m\u00e9todos  111 ar, 146 colitis ulcerosa y muestras de adn de tres grupos de diferente origen \u00e9tnico: 138 individuos espa\u00f1oles, 51 vascos y 95 gitanos. El grupo control: adn de 105 individuos sanos y muestras de adn de 213 individuos sanos; 105 de barcelona y 108 de amesterdam.  resultados  resultados publicados en 6 revistas nacionales e internacionales indexadas.  conclusiones  el estudio genot\u00edpico de tpmt identifica enfermos con: alto riesgo de desarrollar una toxicidad severa (tpmt ll), variantes al\u00e9licas asociadas con actividad intermedia (tpmt hl) un genotipo normal (tomt hh), en este grupo, se pueden prescribir dosis m\u00e1s altas, sin riesgo aparente de toxicidad para conseguir una mejor respuesta terap\u00e9utica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacogenetica de los enzimas metabolicos: el ejemplo de la tiopurina s-metiltransferasa (tpmt) y el metabolismo de azatioprina en las enfermedades inflamatorias cronicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacogenetica de los enzimas metabolicos: el ejemplo de la tiopurina s-metiltransferasa (tpmt) y el metabolismo de azatioprina en las enfermedades inflamatorias cronicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hector Corominas Mac\u00edas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Baiget Bast\u00fas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>alejandro Oliv\u00e9 marqu\u00e9s (vocal)<\/li>\n<li>jordi Carbonell abello (vocal)<\/li>\n<li>Manuel j Barbanoj rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hector Corominas Mac\u00edas Objetivo 1,- analizar los polimorfismos de tiopurina s- metiltransfersa (tpmt). 2,- describir las mutaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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