{"id":68987,"date":"2004-02-07T00:00:00","date_gmt":"2004-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-del-peptido-inhibidor-p144r-del-factor-transformante-del-crecimiento-beta1-tgf-beta1-en-la-fibrosis-capsular-periprotesica-tras-implantes-de-silicona-en-ratas\/"},"modified":"2004-02-07T00:00:00","modified_gmt":"2004-02-07T00:00:00","slug":"utilizacion-del-peptido-inhibidor-p144r-del-factor-transformante-del-crecimiento-beta1-tgf-beta1-en-la-fibrosis-capsular-periprotesica-tras-implantes-de-silicona-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/utilizacion-del-peptido-inhibidor-p144r-del-factor-transformante-del-crecimiento-beta1-tgf-beta1-en-la-fibrosis-capsular-periprotesica-tras-implantes-de-silicona-en-ratas\/","title":{"rendered":"Utilizaci\u00f3n del p\u00e9ptido inhibidor (p144(r)) del factor transformante del crecimiento beta1 (tgf-beta1) en la fibrosis capsular periprot\u00e9sica tras implantes de silicona en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ruiz De Erenchun Purroy Ricardo <\/strong><\/h2>\n<p>La contractura capsular es la complicaci\u00f3n espec\u00edfica m\u00e1s frecuente relacionada con las pr\u00f3tesis de silicona, atribuida a una retracci\u00f3n lenta y progresiva del tejido fibroso cicatricial formado alrededor de la pr\u00f3tesis. Su imprevisible aparici\u00f3n, variable en el tiempo, se manifiesta desde un ligero endurecimiento hasta una deformidad evidente provocando asimetr\u00edas, molestias, e incluso ruptura de la pr\u00f3tesis y dificultad en la expansi\u00f3n tisular.  la biolog\u00eda molecular ha permitido determinar el papel del factor transformante del crecimiento beta (tgf-beta) en la fisiopatolog\u00eda cicatricial de cualquier proceso fibr\u00f3tico, incluido la fibrosis capsular periprot\u00e9sica, fen\u00f3meno precursor de la contractura capsular.  el prop\u00f3sito de este estudio es valorar la efectivida e un inhibidor pept\u00eddico de tgf-beta1 (p144(r)) de reciente s\u00edntesis, en la fibrosis periprot\u00e9sica tras implantes de silicona en ratas.  se formaron para ello tres grupos experimentales: en el primero, las pr\u00f3tesis tanto subcut\u00e1neas como submusculares, no sufrieron tratamiento alguno; en el segundo, se procedi\u00f3 a la inyecci\u00f3n periprot\u00e9sica de suero fisiol\u00f3gico con dimetil-sulf\u00f3xido (dmso) durante 4 semanas a d\u00edas alternos; en el tercer grupo y siguiendo el mismo protocolo que el grupo anterior, la inyecci\u00f3n periprot\u00e9sica se realiz\u00f3 con el inhibidor de tgf-beta1. Los animales fueron sacrificados transcurridas ocho semanas de la implantaci\u00f3n valor\u00e1ndose las c\u00e1psulas macrosc\u00f3pica e histol\u00f3gicamente. Se realiz\u00f3 as\u00ed mismo un estudio toxicol\u00f3gico de series hematol\u00f3gicas y de \u00f3rganos diana.  tras el estudio se comprob\u00f3 que la aplicaci\u00f3n del p\u00e9ptido inhibidor de tgf-beta1 es significativamente eficaz en reducir el grosor y la celularidad total capsular, independientemente de la localizaci\u00f3n del implante, sin efectos de toxicidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n del p\u00e9ptido inhibidor (p144(r)) del factor transformante del crecimiento beta1 (tgf-beta1) en la fibrosis capsular periprot\u00e9sica tras implantes de silicona en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n del p\u00e9ptido inhibidor (p144(r)) del factor transformante del crecimiento beta1 (tgf-beta1) en la fibrosis capsular periprot\u00e9sica tras implantes de silicona en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ruiz De Erenchun Purroy Ricardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernardo Hontanilla Calatayud<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pilar Civeira murillo <\/li>\n<li>alfonso Abascal zuloaga (vocal)<\/li>\n<li>vicente Paloma mora (vocal)<\/li>\n<li> Rodrigo cucal\u00f3n Miguel \u00e1ngel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruiz De Erenchun Purroy Ricardo La contractura capsular es la complicaci\u00f3n espec\u00edfica m\u00e1s frecuente relacionada con las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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