{"id":6907,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/perspectivas-en-el-tratamiento-de-la-intoxicacion-aluminica-con-el-quelante-del-hierro-l112-dimetil-3-hidroxipiridin-4-ona\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"perspectivas-en-el-tratamiento-de-la-intoxicacion-aluminica-con-el-quelante-del-hierro-l112-dimetil-3-hidroxipiridin-4-ona","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/perspectivas-en-el-tratamiento-de-la-intoxicacion-aluminica-con-el-quelante-del-hierro-l112-dimetil-3-hidroxipiridin-4-ona\/","title":{"rendered":"Perspectivas en el tratamiento de la intoxicacion aluminica con el quelante del hierro l1(1,2-dimetil-3-hidroxipiridin-4-ona)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosario Elorriaga Fernandez <\/strong><\/h2>\n<p>A) \u00abin vivo\u00bb.- En ratas wistar macho con insuficiencia renal cronica e intoxicacion aluminica, se evaluo la movilizacion del aluminio tisular, tras 6 semanas de tratamiento con el nuevo quelante l1 o 1,2-dimetil-3-hidroxipiridin-4-ona, administrado por via oral, comparando a la vez su eficacia con dosis equivalentes del quelante habitual desferrioxamina (dfo) y con un placebo administrado por via oral. La l1, fue tan efectiva como la dfo movilizando aluminio del tejido oseo; si bien la l1 mostro un efecto mas especifico a nivel histologico, aumentando con mayor eficacia, que la dfo y el placebo, la cantidad de hueso mineralizado.  b) \u00abin vitro\u00bb.- Se evaluo el efecto de la l1 sobre la proliferacion de la linea celular con caracteristicas de \u00abpreosteoblasto\u00bb mg-63, ademas del efecto de elevadas concentraciones de aluminio y hierro (50 y 100 um) sobre la proliferacion de esta misma linea celular. La l1 mostro un efecto inhibitorio sobre la proliferacion, dosis dependiente y reversible por coadicion de hierro al medio de cultivo, y por el contrario el hierro y el aluminio aumentaron la proliferacion en estas celulas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perspectivas en el tratamiento de la intoxicacion aluminica con el quelante del hierro l1(1,2-dimetil-3-hidroxipiridin-4-ona).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perspectivas en el tratamiento de la intoxicacion aluminica con el quelante del hierro l1(1,2-dimetil-3-hidroxipiridin-4-ona). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosario Elorriaga Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Gomez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Alvarez Grande <\/li>\n<li>Marina Costales Perez (vocal)<\/li>\n<li>Andr\u00e9s Sampedro Nu\u00f1o (vocal)<\/li>\n<li>Jeremy Brock (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosario Elorriaga Fernandez A) \u00abin vivo\u00bb.- En ratas wistar macho con insuficiencia renal cronica e intoxicacion aluminica, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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