{"id":69080,"date":"2004-06-07T00:00:00","date_gmt":"2004-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-endostatina-inhibe-el-eecto-prometastatico-del-vegf-durante-la-metastasis-experimental-del-melanoma\/"},"modified":"2004-06-07T00:00:00","modified_gmt":"2004-06-07T00:00:00","slug":"la-endostatina-inhibe-el-eecto-prometastatico-del-vegf-durante-la-metastasis-experimental-del-melanoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/la-endostatina-inhibe-el-eecto-prometastatico-del-vegf-durante-la-metastasis-experimental-del-melanoma\/","title":{"rendered":"La endostatina inhibe el eecto prometastatico del vegf durante la metastasis experimental del melanoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Valcarcel Cuesta <\/strong><\/h2>\n<p>La endostatina  es una mol\u00e9cula end\u00f3gena que regula la quiescencia vascular e inhibe la angiog\u00e9nesis tumoral porque bloquea la proliferaci\u00f3n, migraci\u00f3n y apopt\u00f3sis de las c\u00e9lulas endoteliales. A pesar del importante conocimiento sobre sus efectos tumorales, se desconoce su mecanismo de acci\u00f3n sobre los estadios preangiog\u00e9nicos y postangiog\u00e9nicos que contribuyen a la colonizaci\u00f3n tumoral del h\u00edgado. El presente estudio se plante\u00f3 para estudiar el efecto de la endostatina sobre el mecanismos pro-metast\u00e1tico de la inflamaci\u00f3n microvascular inducido por el vegf que deriva de c\u00e9lulas tumorales, a trav\u00e9s de un modelo de colonizaci\u00f3n hep\u00e1tica por c\u00e9lulas del melanoma b16, dependiente de la adhesi\u00f3n a c\u00e9lulas endoteliales v\u00eda vcam-1 inducida por tnf-alfa e il-18. As\u00ed mismo, se estudi\u00f3 los efectos del vegf y la endostatina sobre el potencial proadhesivo del melanoma v\u00eda vla-4, y sus consecuencias sobre la retenci\u00f3n microvascular hep\u00e1tica y la formaci\u00f3n de metast\u00e1sis. Por \u00faltimo el proyecto se centr\u00f3 en la actividad metast\u00e1tico y angiog\u00e9nica del melanoma en el h\u00edgado de ratones tratados con endostatina, con particular atenci\u00f3n a sus efectos sobre los mecanismos de migraci\u00f3n proangiog\u00e9nica endotelial y de los miofibroblastos preivasculares; y de proliferaci\u00f3n y migraci\u00f3n tumoral, inducidos por el vegf.  los resultados obtenidos demuestran que el tratamiento con endostatina durante la etapa de diseminaci\u00f3n hep\u00e1tica del mb16 disminuy\u00f3, por una parte, la implantaci\u00f3n y el desarrollo de met\u00e1stasis a trav\u00e9s de su efecto inhibidor sobre la retenci\u00f3n microvascular de c\u00e9lulas tumorales circulantes. En este mismo escenario de implantaci\u00f3n metast\u00e1tica, el vegf tambi\u00e9n estimul\u00f3 la adhesividad del mb16 al endotelio sinusoidal hep\u00e1tico a trave\u00e9s de un mecanismo regulado por la activaci\u00f3n de la integrina vla-4 a trav\u00e9s de tnfa inducido por il-18. Por otra parte, la administraci\u00f3n de endostatina recombinante<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La endostatina inhibe el eecto prometastatico del vegf durante la metastasis experimental del melanoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La endostatina inhibe el eecto prometastatico del vegf durante la metastasis experimental del melanoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Valcarcel Cuesta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bonifacio nicol\u00e1s Diaz chico <\/li>\n<li>anna Mar\u00eda Bassols teixido (vocal)<\/li>\n<li>Rafael De llorens duran (vocal)<\/li>\n<li>jaume Piulats xanc\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Valcarcel Cuesta La endostatina es una mol\u00e9cula end\u00f3gena que regula la quiescencia vascular e inhibe la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[13698,16660,12983,53282,151421,18819],"class_list":["post-69080","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-anna-maria-bassols-teixido","tag-bonifacio-nicolas-diaz-chico","tag-fernando-vidal-vanaclocha","tag-jaume-piulats-xanco","tag-maria-valcarcel-cuesta","tag-rafael-de-llorens-duran"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/69080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=69080"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/69080\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=69080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=69080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=69080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}