{"id":69254,"date":"2004-09-07T00:00:00","date_gmt":"2004-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-radicales-libres-y-el-oxido-na%c2%adtrico-en-el-adenocarcinoma-inducido-en-un-modelo-de-esofago-de-barret-en-rata-y-efecto-de-la-quimioprevencion\/"},"modified":"2004-09-07T00:00:00","modified_gmt":"2004-09-07T00:00:00","slug":"papel-de-los-radicales-libres-y-el-oxido-na%c2%adtrico-en-el-adenocarcinoma-inducido-en-un-modelo-de-esofago-de-barret-en-rata-y-efecto-de-la-quimioprevencion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/papel-de-los-radicales-libres-y-el-oxido-na%c2%adtrico-en-el-adenocarcinoma-inducido-en-un-modelo-de-esofago-de-barret-en-rata-y-efecto-de-la-quimioprevencion\/","title":{"rendered":"Papel de los radicales libres y el \u00f3xido n\u00edtrico en el adenocarcinoma inducido en un modelo de es\u00f3fago de barret en rata y efecto de la quimioprevenci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmelo Cebri\u00e1n Garc\u00eda <\/strong><\/h2>\n<p>Introducci\u00f3n: diferentes estudios han demostrado que los radicales libres de ox\u00edgeno, especialmente el ani\u00f3n super\u00f3xido, est\u00e1n involucrados en la patogenia de la enfermedad por reflujo gastroesof\u00e1gico que deriva en adenocarcinoma. se desconoce si la administraci\u00f3n de barredores de radicales libres tiene alg\u00fan efecto protector en la progresi\u00f3n del es\u00f3fago de barrett (eb) a adenocarcinoma. por su parte, al \u00f3xido n\u00edtrico (on) tambi\u00e9n se le ha involucrado en esta secuencia, sin embargo, se desconoce el efecto de la inhibici\u00f3n de su s\u00edntesis en la transformaci\u00f3n neopl\u00e1sica.  m\u00e9todos: en un modelo experimental de eb mediante la creaci\u00f3n de una es\u00f3fago-yeyunostom\u00eda con preservaci\u00f3n del est\u00f3mago se eval\u00faa el desarrollo de eb y adenocarcinoma por meses a lo largo de 3-4 meses de evoluci\u00f3n en cuatro grupos: grupo 1 = operaci\u00f3n ficticia sin reflujo; grupo 2 = es\u00f3fago-yeyunostom\u00eda (e-y) sin tratamiento; grupo 3 = e-y + tratamiento con sod (ontosein = 0.3 mg\/100 g de peso\/ 3 d\u00edas); y grupo 4 = e-y + tratamiento con l-name (inhibidor no selectivo s\u00edntesis de on: 10 mg\/kg\/d\u00eda). Los resultados se eval\u00faan mediante an\u00e1lisis de covarianza y test no param\u00e9tricos (kruskall-wallis y mann-whitney) para las variables cuantitativas. Para las variables cualitativas, se ha ajustado un modelo log\u00edstico, que eval\u00faa conjuntamente el efecto del f\u00e1rmaco y los meses de evoluci\u00f3n.  resultados: el reflujo gastro-duodeno-esof\u00e1gico creado induce una secuencia de lesiones superponible a la erge del humano, con inflamaci\u00f3n, ulceraci\u00f3n e hiperplasia escamosa en todos los casos, desde el primer mes. Se observa aparici\u00f3n de metaplasia intestinal en el es\u00f3fago distal en continuidad con el yeyuno e incremento de su longitud en el tiempo en sentido ascendente, as\u00ed como metaplasia intestinal (c\u00e9lulas caliciformes) sin relaci\u00f3n con la anastomosis que alcanza valores cercanos al m\u00e1ximo ya en el segundo mes (70%). Por \u00faltimo, se constat<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los radicales libres y el \u00f3xido n\u00edtrico en el adenocarcinoma inducido en un modelo de es\u00f3fago de barret en rata y efecto de la quimioprevenci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los radicales libres y el \u00f3xido n\u00edtrico en el adenocarcinoma inducido en un modelo de es\u00f3fago de barret en rata y efecto de la quimioprevenci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmelo Cebri\u00e1n Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Soria navarro <\/li>\n<li> Mart\u00ednez-pe\u00f1uela virseta Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Francisco Esteva d\u00edaz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmelo Cebri\u00e1n Garc\u00eda Introducci\u00f3n: diferentes estudios han demostrado que los radicales libres de ox\u00edgeno, especialmente el ani\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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