{"id":69272,"date":"2004-09-07T00:00:00","date_gmt":"2004-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/isolation-structural-characterisation-and-pharmacological-properties-of-bioactive-saponins-from-corms-of-crocus-sativus-l\/"},"modified":"2004-09-07T00:00:00","modified_gmt":"2004-09-07T00:00:00","slug":"isolation-structural-characterisation-and-pharmacological-properties-of-bioactive-saponins-from-corms-of-crocus-sativus-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/castilla-la-mancha\/isolation-structural-characterisation-and-pharmacological-properties-of-bioactive-saponins-from-corms-of-crocus-sativus-l\/","title":{"rendered":"Isolation, structural characterisation and pharmacological properties of bioactive saponins from corms of crocus sativus l."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angela Rubio Moraga <\/strong><\/h2>\n<p>El trabajo realizado en esta tesis doctoral ha contribuido a mejorar la producci\u00f3n de una fracci\u00f3n cromatogr\u00e1fica altamente citot\u00f3xica contra c\u00e9lulas tumorales (cf) partir de cormo de crocus sativus. Y funcional. Esta fracci\u00f3n est\u00e1 compuesta por un 95% de saponinas y un 5% de prote\u00ednas. Se ha demostrado que las saponinas son responsables de la actividad citot\u00f3xica de cf contra las c\u00e9lulas tumorales hela. Las interacciones i\u00f3nicas entre las saponinas y prote\u00ednas contribuyen a favorecer la solubilidad de las saponinas presentes en cf. Estas interacciones podr\u00edan jugar un papel importante en las propiedades farmacol\u00f3gicas y biol\u00f3gicas de cf.  el an\u00e1lisis estructural ha pemitido determinar que las saponinas son gluc\u00f3sidos del \u00e1cido equinoc\u00edstico con dos tipos de prosapogeninas, p1 como 3-o-b-d-glucuronopiranosil del \u00e1cido equinoc\u00edstico y p2 como 3-o-b-d-galacturonopiranosil del \u00e1cido equinoc\u00edstico. Se trata de las primeras saponinas descritas que tienen \u00e1cido galactur\u00f3nico en su composici\u00f3n. Igualmente se ha encontrado por primera vez gluc\u00f3sidos del \u00e1cido equinoc\u00edstico en una planta monocotiled\u00f3nea. el an\u00e1lisis estructural de la principal fracci\u00f3n cromatogr\u00e1fica de cf demuestra la presencia de dos saponinas bidesmos\u00eddicas, safronina a con p2 como prosapogenina y safronina b con p1 como prosapogenina, presentes en una proporci\u00f3n 3:2 (saffronina a:safronina b). Ambas prosapogeninas est\u00e1n substituidas en la posici\u00f3n c28 con el pentasac\u00e1rido b-d-galactopiranosil-(1(r)2)-a-l-arabinopiranosil-(1(r)2)-[b-d-xilopiranosil-(1(r)4)]-a-l-ramnopiranosil-(1(r)2)-[4-o-acil]-b-d-fucopiranosido.  se ha propuesto que la citotoxicidad de cf contra c\u00e9lulas tumorales es debida a la interacci\u00f3n entre las saponinas y los esteroles de la membrana plasm\u00e1tica originando poros que permiten la entrada de ca2+, la liberaci\u00f3n de prote\u00ednas intracelulares al medio extracelular y consecutivamente la lisis celular. La ausencia de ac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Isolation, structural characterisation and pharmacological properties of bioactive saponins from corms of crocus sativus l.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Isolation, structural characterisation and pharmacological properties of bioactive saponins from corms of crocus sativus l. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angela Rubio Moraga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Castilla-la mancha<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gerrit Johannes Gerwig<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Laborda fernandez <\/li>\n<li>albert Tauler girona (vocal)<\/li>\n<li>nicolaas a j Van nuland (vocal)<\/li>\n<li>rainer Wechselberger (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angela Rubio Moraga El trabajo realizado en esta tesis doctoral ha contribuido a mejorar la producci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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