{"id":69280,"date":"2004-09-07T00:00:00","date_gmt":"2004-09-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-proliferacion-celular-inducida-por-la-oncoproteina-bcr-abl-mediante-el-control-de-la-expresion-de-p27kip1\/"},"modified":"2004-09-07T00:00:00","modified_gmt":"2004-09-07T00:00:00","slug":"estudio-de-la-proliferacion-celular-inducida-por-la-oncoproteina-bcr-abl-mediante-el-control-de-la-expresion-de-p27kip1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cardenal-herrera-ceu\/estudio-de-la-proliferacion-celular-inducida-por-la-oncoproteina-bcr-abl-mediante-el-control-de-la-expresion-de-p27kip1\/","title":{"rendered":"Estudio de la proliferacion celular inducida por la oncoproteina bcr\/abl mediante el control de la expresion de p27kip1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisa Lledo Feijoo <\/strong><\/h2>\n<p>La leucemia mieloide cr\u00f3nica (lmc) es una enfermedad hematol\u00f3gica que resulta de la proliferaci\u00f3n desregulada de una c\u00e9lula troncal hematopoy\u00e9tica pluripotencial. a nivel molecular, la lmc se caracteriza por la expresi\u00f3n de una prote\u00edna quim\u00e9rica, bcr-abl, que presenta una actividad tirosina kinasa aumentada y desregulada. La expresi\u00f3n de esta oncoprote\u00edna resulta en una elevada proliferaci\u00f3n celular y en una inhibici\u00f3n de la muerte celular por apoptosis. la forma bcr-ablp210 es suficiente y necesaria para transformar c\u00e9lulas hematopoy\u00e9ticas y juega un papel muy importante en la inducci\u00f3n de la lmc.  para la realizaci\u00f3n de este trabajo hemos empleado l\u00edneas celulares que expresan bcr-ablp210, tanto de origen murino (baf\/3-p210) como humano (mo7e-p210). el estudio de la actividad de bcr-abl, y su efecto sobre la proliferaci\u00f3n celular, lo hemos llevado a cabo mediante la inhibici\u00f3n espec\u00edfica de la actividad tirosina kinasa de esta oncoprote\u00edna con el f\u00e1rmaco sti571. El tratamiento de las c\u00e9lulas bcr-abl positivas con este inhibidor resulta en una parada del ciclo celular, mientras que en ausencia de \u00e9ste las c\u00e9lulas proliferan de una manera normal y su crecimiento es independiente del aporte de factores externos, como la interleukina-3. El tratamiento de estas c\u00e9lulas con distintos inhibidores de las principales rutas de transducci\u00f3n de se\u00f1ales activadas  por bcr-abl, indica que su efecto sobre la proliferaci\u00f3n celular est\u00e1 mediado principalmente por la v\u00eda de pi3k\/akt.  la inhibici\u00f3n de bcr-abl tambi\u00e9n est\u00e1 asociada a una acumulaci\u00f3n de la prote\u00edna inhibidora del ciclo celular p27kip1, as\u00ed como a una disminuci\u00f3n en la actividad kinasa de los complejos ciclina e\/cdk2. Todas estas prote\u00ednas juegan un papel importante en la regulaci\u00f3n del ciclo celular en la transici\u00f3n g1\/s, y a trav\u00e9s de ellas bcr-abl controla la progresi\u00f3n del ciclo celular en este punto.  nuestro estudio se ha centrado en la r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la proliferacion celular inducida por la oncoproteina bcr\/abl mediante el control de la expresion de p27kip1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la proliferacion celular inducida por la oncoproteina bcr\/abl mediante el control de la expresion de p27kip1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisa Lledo Feijoo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cardenal herrera-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio P\u00e9rez Roger<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roberto (secretario) Erwin knecht <\/li>\n<li>Rafael Pulido murillo (vocal)<\/li>\n<li>Manuel Collado rodr\u00edguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisa Lledo Feijoo La leucemia mieloide cr\u00f3nica (lmc) es una enfermedad hematol\u00f3gica que resulta de la proliferaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[51435],"tags":[151784,12201,90834,50972,151785],"class_list":["post-69280","post","type-post","status-publish","format-standard","hentry","category-cardenal-herrera-ceu","tag-elisa-lledo-feijoo","tag-ignacio-perez-roger","tag-manuel-collado-rodriguez","tag-rafael-pulido-murillo","tag-roberto-secretario-erwin-knecht"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/69280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=69280"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/69280\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=69280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=69280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=69280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}