{"id":69284,"date":"2004-10-07T00:00:00","date_gmt":"2004-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sindrome-de-la-respuesta-inflamatoria-sistemica-experimental-inducida-por-zymosan-a-estudio-comparativo-de-su-regulacion-con-molsidomina-r-tacrolimus-r-y-celecosib-r\/"},"modified":"2004-10-07T00:00:00","modified_gmt":"2004-10-07T00:00:00","slug":"sindrome-de-la-respuesta-inflamatoria-sistemica-experimental-inducida-por-zymosan-a-estudio-comparativo-de-su-regulacion-con-molsidomina-r-tacrolimus-r-y-celecosib-r","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/sindrome-de-la-respuesta-inflamatoria-sistemica-experimental-inducida-por-zymosan-a-estudio-comparativo-de-su-regulacion-con-molsidomina-r-tacrolimus-r-y-celecosib-r\/","title":{"rendered":"Sindrome de la respuesta inflamatoria sistemica experimental inducida por zymosan a. estudio comparativo de su regulacion con molsidomina (r), tacrolimus (r) y celecosib (r)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Gomez Castro <\/strong><\/h2>\n<p>Se trata de estudiar la influencia de tres f\u00e1rmacos: un donador de on (molsidomina), un inmusupresor (tacrolimus), y un inhibidor de la cox-2. Sobre un modelo experimental previamente establecido y que consiste en la administraci\u00f3n intraperitoneal de zymosan a. Se han hecho controles de mediadores de la inflamaci\u00f3n, radicales libres de oxigeno, traslocaci\u00f3n bacteriana, mol\u00e9culas de adhesi\u00f3n, factor de transcripci\u00f3n nuclear, etc.  por otra parte se ha estudiado tambi\u00e9n la agresividad de el modelo experimental controlando la supervivencia de los animales y ajustando la dosis de zymosan a para la valoraci\u00f3n de los objetivos que se pretend\u00edan.  de la valoraci\u00f3n de los resultados cabe deducir que el donador de on es el que m\u00e1s ha influido en los controles referidos objetiv\u00e1ndose un beneficio evidente en cuanto a la traslocaci\u00f3n bacteriana, mediadores de la inflamaci\u00f3n, radicales libres, etc.  en cuanto a los otros dos f\u00e1rmacos, se ha evidenciado un efecto beneficioso del inmunosupresor aunque menos manifiesto que la molsidomina; y en cuanto al inhibidor de la cox-2 (celecoxib), los beneficios han sido menos evidentes y se discute sobre si el modelo inflamatorio empleado (inflamaci\u00f3n aguda de alta mortalidad) deber\u00eda modificarse para el estudio a largo plazo de este medicamento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sindrome de la respuesta inflamatoria sistemica experimental inducida por zymosan a. estudio comparativo de su regulacion con molsidomina (r), tacrolimus (r) y celecosib (r).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sindrome de la respuesta inflamatoria sistemica experimental inducida por zymosan a. estudio comparativo de su regulacion con molsidomina (r), tacrolimus (r) y celecosib (r). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Gomez Castro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Gomez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Martinez rodriguez <\/li>\n<li>Jaime Mendez martin (vocal)<\/li>\n<li>Francisco Lozano sanchez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Gomez Castro Se trata de estudiar la influencia de tres f\u00e1rmacos: un donador de on (molsidomina), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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