{"id":69375,"date":"2018-03-09T23:13:51","date_gmt":"2018-03-09T23:13:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-control-metabolico-sobre-las-respuestas-endotelio-dependientes-en-la-diabetes-mellitus-tipo-1-posibles-mecanismos-implicados\/"},"modified":"2018-03-09T23:13:51","modified_gmt":"2018-03-09T23:13:51","slug":"efecto-del-control-metabolico-sobre-las-respuestas-endotelio-dependientes-en-la-diabetes-mellitus-tipo-1-posibles-mecanismos-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-control-metabolico-sobre-las-respuestas-endotelio-dependientes-en-la-diabetes-mellitus-tipo-1-posibles-mecanismos-implicados\/","title":{"rendered":"Efecto del control metab\u00f3lico sobre las respuestas endotelio-dependientes en la diabetes mellitus tipo 1. posibles mecanismos implicados."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro L\u00f3pez-d\u00f3riga Bonnardeaux <\/strong><\/h2>\n<p>Hip\u00f3tesis: el grado de control metab\u00f3lico de la diabetes mellitus (dm) tipo 1 explica el deterioro observado en las respuestas vasculares endotelio-dependientes en el cual participar\u00eda el estr\u00e9s oxidativo; la hemoglobina glicada podr\u00eda tener un papel fisiopatol\u00f3gico en dicho deterioro. M\u00e9todos: mediante pletismograf\u00eda por oclusi\u00f3n venosa se estudiaron in vivo la liberaci\u00f3n basal y estimulada de \u00f3xido n\u00edtrico (on) por el endotelio (curva dosis respuesta a l-nmma y a metacolina, respectivamente), as\u00ed como la respuesta de la pared vascular a on no endotelio-dependiente (curva dosis-respuesta a nitroprusiato s\u00f3dico) en sujetos control (n= 14) y sujetos diab\u00e9ticos tipo 1 clasificados de acuerdo al grado de control metab\u00f3lico: bien controlados (hba1c &lt; 7,5%) y mal controlados (hba1c = 7,5%).  Para evaluar la posible participaci\u00f3n de radicales super\u00f3xido, se repiti\u00f3 la curva dosis-respuesta a metacolina en presencia de super\u00f3xido dismutasa. Mediante el registro de los cambios en la tensi\u00f3n isom\u00e9trica (mi\u00f3grafo de mulvany) de segmentos vasculares procedentes de microvasos de epiplon humano se estudi\u00f3 el efecto de la hemoglobina humana glicada (hbhg) con diferentes porcentajes de glicaci\u00f3n en la relajaci\u00f3n inducida por bradiquinina (bk); los componentes de la relajaci\u00f3n inducida por bk sensibles al efecto de la hbhg; y la posible participaci\u00f3n de diferentes radicales libres en el deterioro causado por la hbhg. Resultados: se observ\u00f3 un deterioro en la liberaci\u00f3n basal y estimulada de on y en la respuesta vascular al on exclusivamente en los diab\u00e9ticos con mal control respecto al grupo control, pero no en los diab\u00e9ticos con buen control metab\u00f3lico. La liberaci\u00f3n estimulada de on mejoraba parcialmente con la coinfusi\u00f3n de super\u00f3xido dismutasa en los diab\u00e9ticos mal controlados. la hbhg  produjo un deterioro en la relajaci\u00f3n a bk en segmentos de microvasos de epiplon humano precontra\u00eddos con potasio; este efecto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del control metab\u00f3lico sobre las respuestas endotelio-dependientes en la diabetes mellitus tipo 1. posibles mecanismos implicados.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del control metab\u00f3lico sobre las respuestas endotelio-dependientes en la diabetes mellitus tipo 1. posibles mecanismos implicados. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro L\u00f3pez-d\u00f3riga Bonnardeaux <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Leocadio Rodr\u00edguez Ma\u00f1as<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li> Pallardo s\u00e1nchez Juan  felipe (vocal)<\/li>\n<li>Manuel Serrano rios (vocal)<\/li>\n<li>Manuel Rodr\u00edguez puyol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro L\u00f3pez-d\u00f3riga Bonnardeaux Hip\u00f3tesis: el grado de control metab\u00f3lico de la diabetes mellitus (dm) tipo 1 explica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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