{"id":69418,"date":"2018-03-09T23:13:55","date_gmt":"2018-03-09T23:13:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/jnk-mkp-and-pi3k-nfkb-the-major-pathways-controlling-cellular-response-towards-cisplatin-in-non-small-cell-lung-cancer\/"},"modified":"2018-03-09T23:13:55","modified_gmt":"2018-03-09T23:13:55","slug":"jnk-mkp-and-pi3k-nfkb-the-major-pathways-controlling-cellular-response-towards-cisplatin-in-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/jnk-mkp-and-pi3k-nfkb-the-major-pathways-controlling-cellular-response-towards-cisplatin-in-non-small-cell-lung-cancer\/","title":{"rendered":"Jnk-mkp! and pi3k-nfkb: the major pathways controlling cellular response towards cisplatin in non small cell lung cancer."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sharmila Chattopadhyay <\/strong><\/h2>\n<p>El c\u00e1ncer de pulm\u00f3n es una de las peores enfermedades de nuestro mundo. el diagnostico se hace en general tarde y la supervivencia es baja. El carcinoma no microcitico de pulm\u00f3n (cnmp) representa el tipo de tumor mas frecuente y con peor pron\u00f3stico de c\u00e1ncer de pulm\u00f3n. Optimizar la inducci\u00f3n de apoptosis en este tipo de tumor representa una forma l\u00f3gica de avanzar en el tratamiento de la enfermedad. Las l\u00edneas derivadas e carcinoma o microc\u00edtico de pulm\u00f3n tienen diferentes grados de sensibilidad a cisplatino, el f\u00e1rmaco mas frecuentemente usado solo o en combinaciones para el tratamiento de este tumor. Este f\u00e1rmaco induce diferencialmente la activaci\u00f3n de jnk, que a su vez media la inducci\u00f3n de apoptosis. Mkp1\/cl100 un regulador negativo de jnk, se encuentra sobreexpresada en varias l\u00edneas celulares de cnmp, nosotros la hemos encontrado sobreexpresada en c\u00e9lulas h460. Expresando sirna contra mkp1 en esta l\u00ednea celular, hemos encontrado que el cisplatino induce mas eficientemente la activaci\u00f3n de jnk y p38 y esto correlaciona con un aumento de 10 veces, en la sensibilidad a cisplatino y con un menor crecimiento de los tumores inducidos por estas l\u00edneas en ratones. Cuando se analizan muestras quir\u00fargicas de pacientes con cnmp  hemos encontrado expresi\u00f3n de mkp1 con localizaci\u00f3n nuclear en el 80% de los casos. En conjunto los resultados muestran que la inhibici\u00f3n de la expresi\u00f3n de mkp1 contribuye a un menor crecimiento de la l\u00ednea celular en el tumor y tambi\u00e9n un aumento de la respuesta a cisplatino  sugiriendo que mkp1 representa una buena diana para sensibilizar este tipo de tumores a cisplatino.  hemos buscado otras dianas que modifiquen la respuesta en otras l\u00edneas mas resistentes a cisplatino como la l\u00ednea celular h727 y h1299 y hemos encontrado la ruta de nf b la cual se conoce es activada por la ruta pi3k\/akt. en ambas l\u00edneas celulares h727 y h1299 hemos encontrado altos niveles de actividad nf b, por tan<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Jnk-mkp! and pi3k-nfkb: the major pathways controlling cellular response towards cisplatin in non small cell lung cancer.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Jnk-mkp! and pi3k-nfkb: the major pathways controlling cellular response towards cisplatin in non small cell lung cancer. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sharmila Chattopadhyay <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Perona Abellon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Lacal sanJuan <\/li>\n<li>Manuel Nistal mart\u00edn de serrano (vocal)<\/li>\n<li>Manuel G\u00f3nzalez bar\u00f3n (vocal)<\/li>\n<li>carme Caelles franch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sharmila Chattopadhyay El c\u00e1ncer de pulm\u00f3n es una de las peores enfermedades de nuestro mundo. el diagnostico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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