{"id":69486,"date":"2018-03-09T23:13:58","date_gmt":"2018-03-09T23:13:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citoquinas-y-estres-oxidativo-en-la-fisiopatologa%c2%ada-de-la-pancreatitis-aguda-experimental-implicaciones-terapeuticas\/"},"modified":"2018-03-09T23:13:58","modified_gmt":"2018-03-09T23:13:58","slug":"citoquinas-y-estres-oxidativo-en-la-fisiopatologa%c2%ada-de-la-pancreatitis-aguda-experimental-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citoquinas-y-estres-oxidativo-en-la-fisiopatologa%c2%ada-de-la-pancreatitis-aguda-experimental-implicaciones-terapeuticas\/","title":{"rendered":"Citoquinas y estr\u00e9s oxidativo en la fisiopatolog\u00eda de la pancreatitis aguda experimental. implicaciones terap\u00e9uticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cassinello Fernandez Norberto <\/strong><\/h2>\n<p>Introducci\u00f3n: de las complicaciones sist\u00e9micas que caracterizan a la pancreatitis aguda (pa) grave la afectaci\u00f3n pulmonar es responsable del 60% de la mortalidad durante la primera semana. En  la fisiopatolog\u00eda de la pancreatitis aguda grave est\u00e1n implicados los mediadores de la inflamaci\u00f3n, entre los que destacan el estr\u00e9s oxidativo y el factor de necrosis tumoral alfa (tnf- ).  hip\u00f3tesis: la inhibici\u00f3n simult\u00e1nea de la producci\u00f3n de tnf-  (con pentoxifilina) y de la actividad de xantina oxidasa (con oxipurinol) ser\u00eda capaz de prevenir las complicaciones sist\u00e9micas y reducir la mortalidad de la pa grave experimental.  objetivos: determinar la evoluci\u00f3n en el tiempo de la actividad xantina oxidasa y de los niveles de tnf- . Estudiar el efecto de la administraci\u00f3n de pentoxifilina y oxipurinol, tanto de forma individual como combinada, sobre los par\u00e1metros inflamatorios, de estr\u00e9s oxidativo y sobre la mortalidad de la pa grave en el momento donde la lesi\u00f3n pulmonar y pancre\u00e1tica est\u00e1 bien establecida  material y m\u00e9todos: la pa grave se induce mediante perfusi\u00f3n retr\u00f3grada de taurocolato al 3.5% en conducto biliopancre\u00e1tico de ratas wistar macho de entre 250-300 g. Para la primera parte (time course) se realizan determinaciones a las 0, 1, 3, 6 y 9 horas. Para la segunda parte del trabajo se realizan cinco grupos: sham, pa sin tratamiento, pa + pentoxifilina, pa + oxipurinol y pa + pentoxifilina + oxipurinol. Finalmente se elaboraron dos grupos para comparar la supervivencia del grupo de animales sin tratamiento frente al grupo al que se administra el tratamiento combinado  resultados: a las 6 horas tras la inducci\u00f3n de la pancreatitis se produce un aumento significativo en la actividad lipasa plasm\u00e1tica, los niveles de tnf-  total, la actividad mieloperoxidasa (mpo) pulmonar, el cociente entre glutati\u00f3n oxidado\/reducido en p\u00e1ncreas y pulm\u00f3n. La eficacia de los diferentes tratamientos se compar\u00f3 en ese i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citoquinas y estr\u00e9s oxidativo en la fisiopatolog\u00eda de la pancreatitis aguda experimental. implicaciones terap\u00e9uticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citoquinas y estr\u00e9s oxidativo en la fisiopatolog\u00eda de la pancreatitis aguda experimental. implicaciones terap\u00e9uticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cassinello Fernandez Norberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Lledo Matoses<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pascual Parrilla paricio <\/li>\n<li>Francisco Sanchez bueno (vocal)<\/li>\n<li>Jos\u00e9 Vi\u00f1a ribes (vocal)<\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cassinello Fernandez Norberto Introducci\u00f3n: de las complicaciones sist\u00e9micas que caracterizan a la pancreatitis aguda (pa) grave la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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