{"id":69531,"date":"2018-03-09T23:13:58","date_gmt":"2018-03-09T23:13:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-in-situ-de-la-infeccion-osea-gentamicina-versus-ciprofloxacino\/"},"modified":"2018-03-09T23:13:58","modified_gmt":"2018-03-09T23:13:58","slug":"tratamiento-in-situ-de-la-infeccion-osea-gentamicina-versus-ciprofloxacino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/tratamiento-in-situ-de-la-infeccion-osea-gentamicina-versus-ciprofloxacino\/","title":{"rendered":"Tratamiento in situ de la infecci\u00f3n osea. gentamicina versus ciprofloxacino"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Alcover Heriberto Oscar <\/strong><\/h2>\n<p>El objetivo de este trabajo es la evaluaci\u00f3n de la eficacia terap\u00e9utica de implantes biodegradables de cesi\u00f3n sostenida de gentamicina o ciprofloxacino para el tratamiento local de osteomielitis por staphylococcus aureus, provocada en el f\u00e9mur de conejo. Para ello se elaboraron implantes compuestos por una mezcla de fosfatos c\u00e1lcicos (hidroxiapatita y fosfato tric\u00e1lcico) y polil\u00e1ctico (pla) conteniendo un 10% de gentamicina o un 10% de ciprofloxacino.  la esterilizaci\u00f3n de estos sistemas se llev\u00f3 a cabo por irradiaci\u00f3n y, una vez esterilizados, se procedi\u00f3 a su evaluaci\u00f3n y caracterizaci\u00f3n in vitro. Los resultados indicaron que la cesi\u00f3n de gentamicina in vitro desde los implantes conteniendo una carga pr\u00f3xima al 10%, result\u00f3 demasiado r\u00e1pida para el tratamiento local de una osteomielitis, por lo que fueron descartados para su evaluaci\u00f3n in vivo.  para comprobar la eficacia de los implantes de ciprofloxacino se utilizaron par\u00e1metros bacteriol\u00f3gicos, biol\u00f3gicos, hematol\u00f3gicos y bioqu\u00edmicos, signos cl\u00ednicos indicadores en la infecci\u00f3n, radiol\u00f3gicos e histol\u00f3gicos.  la eficacia terap\u00e9utica de los implantes de ciprofloxacino se puso de manifiesto a trav\u00e9s de la disminuci\u00f3n progresiva de unidades vaibles en el foco de infecic\u00f3n, del aumento de peso, disminuci\u00f3n del n\u00famero de leucocitos, plquetas, niveles de prote\u00edna  c-reactiva (pcr) e \u00edndice de gravedad de los signos cl\u00ednicos; desde el punto de vista radiol\u00f3gico, se confirm\u00f3 por la no progresi\u00f3n de signos radiogr\u00e1ficos indicadores de infecci\u00f3n y la integraci\u00f3n del implante en la estructura \u00f3sea afectada; en el an\u00e1lisis anatomopatol\u00f3gicos se parecia inicialmente un proceso inflamatorio infeccioso, que desaparece con el tiempo, mientras tiene lugar una respuesta reparativa y la progresiva invasi\u00f3n del implante por neoformaci\u00f3n \u00f3sea.  por lo tanto, los implantes de ciprofloxacino fueron terap\u00e9uticamente eficaces para el tratamiento de la infecci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento in situ de la infecci\u00f3n osea. gentamicina versus ciprofloxacino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento in situ de la infecci\u00f3n osea. gentamicina versus ciprofloxacino <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Alcover Heriberto Oscar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther S\u00e1nchez S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Gutierrez navarro <\/li>\n<li>Mar\u00eda  dolores Torres l\u00f3pez (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Blanco prieto (vocal)<\/li>\n<li>armando Brito Santiago (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Alcover Heriberto Oscar El objetivo de este trabajo es la evaluaci\u00f3n de la eficacia terap\u00e9utica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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