{"id":69535,"date":"2018-03-09T23:14:02","date_gmt":"2018-03-09T23:14:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-moleculares-del-efecto-neuroprotector-del-ngf-frente-a-genotoxicos\/"},"modified":"2018-03-09T23:14:02","modified_gmt":"2018-03-09T23:14:02","slug":"estudio-de-los-mecanismos-moleculares-del-efecto-neuroprotector-del-ngf-frente-a-genotoxicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-moleculares-del-efecto-neuroprotector-del-ngf-frente-a-genotoxicos\/","title":{"rendered":"Estudio de los mecanismos moleculares del efecto neuroprotector del ngf frente a genot\u00f3xicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Mart\u00ednez Gomariz <\/strong><\/h2>\n<p>En este trabajo hemos estudiado el efecto del tratamiento con ngf sobre la viabilidad frente al tratamiento con agentes genot\u00f3xicos como son la luz ultravioleta (uvc), el cisplatino (cddp) y la camptotecina (cpt) en c\u00e9lulas pc12. Nuestros datos muestran que las c\u00e9lulas que han sido pretratadas con ngf son menos sensibles a estos agentes, esto lleva a un retraso en la ejecuci\u00f3n del fen\u00f3meno de muerte celular programada o apoptosis dependiente de las v\u00edas que desencadena el ngf por su interaci\u00f3n con el receptor trka.  la cin\u00e9tica de activaci\u00f3n de p53 en respuesta a luz uvc no se ve modificada por el pretratamiento con ngf, as\u00ed como tampoco la activaci\u00f3n de la quinasa de c-jun a pesar de que el ngf induce la expresi\u00f3n de la fosfatasa dual espec\u00edfica mkp-1.  el ngf activa las rutas de superviviencia erk y akt. S\u00f3lo la ruta de akt parece participar en la protecci\u00f3n del ngf frente a estos agentes. Otra v\u00eda que se activa por el ngf en las c\u00e9lulas pc12 es la del factor de transcripci\u00f3n nf b. Esta activaci\u00f3n en respuesta a ngf es independiente de la degradaci\u00f3n de su subunidad inhibitoria i b y parece ser debida al aumento de la actividad transcripcional de su subunidad p65\/rela, mediada por fosforilaci\u00f3n dependiente de akt. La activaci\u00f3n de nf b por el ngf induce la expresi\u00f3n de diferentes genes de superviviencia pero ninguno de ellos parece ser responsable del efecto neuroprotector del ngf frente a la luz uvc.  otros factores de transcripci\u00f3n cuya actividad es modulada por akt son los pertenencientes a la familia forkhead. El ngf es capaz de bloquear la inducci\u00f3n de la transcripci\u00f3n g\u00e9nica dependiente de forkhead. Uno de los genes que posee secuencias regulables por forkhead es l-fas. L-fas se induce en respuesta a uvc en las c\u00e9lulas pc12 y el ngf es capaz de bloquear esta expresi\u00f3n, de forma dependiente de la activaci\u00f3n de la quinasa akt. estos resultados nos hacen pensar que el ngf retrasa la apoptosis inducida<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos moleculares del efecto neuroprotector del ngf frente a genot\u00f3xicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos moleculares del efecto neuroprotector del ngf frente a genot\u00f3xicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Mart\u00ednez Gomariz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosario Perona Abellon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Aranda iriarte <\/li>\n<li>Juan  angel Fresno vara (vocal)<\/li>\n<li>Antonio Chiloeches galvez (vocal)<\/li>\n<li>purificacion Mu\u00f1oz canoves (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Mart\u00ednez Gomariz En este trabajo hemos estudiado el efecto del tratamiento con ngf sobre la viabilidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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