{"id":69536,"date":"2018-03-09T23:14:02","date_gmt":"2018-03-09T23:14:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-estructurales-de-la-asociacion-y-evolucion-molecular-de-la-metionina-adenosiltransferasa\/"},"modified":"2018-03-09T23:14:02","modified_gmt":"2018-03-09T23:14:02","slug":"aspectos-estructurales-de-la-asociacion-y-evolucion-molecular-de-la-metionina-adenosiltransferasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-estructurales-de-la-asociacion-y-evolucion-molecular-de-la-metionina-adenosiltransferasa\/","title":{"rendered":"Aspectos estructurales de la asociaci\u00f3n y evoluci\u00f3n molecular de la metionina adenosiltransferasa"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Perez Gabino Francisco <\/strong><\/h2>\n<p>En cirrosis alcog\u00f3lica y otras enfermedades hep\u00e1ticas se ha encontrado una alteraci\u00f3n en la proporci\u00f3n de d\u00edmeros y tetr\u00e1meros de la enzima metionina adenosiltransferasa (mat). Nuestro inter\u00e9s se ha centrado en elucidar el mecanismo molecular por el que se controla la relaci\u00f3n entre ambas formas oligom\u00e9ricas. En primer lugar, utilizando dos sistemas de replegamiento in vitro, se pudo determinar que la formaci\u00f3n del puente disulfuro intramolecular entre las ciste\u00ednas 35 y 61 bloquea la interconversi\u00f3n entre d\u00edmeros y tetr\u00e1meros. Estas ciste\u00ednas se localizan en la l\u00e1mina beta b, donde tambi\u00e9n se han identificado los residuos implicados en las interacciones entre d\u00edmeros en la mat de h\u00edgado de rata. Cuando se mutaron y se sobreexpresaron en escherichia coli, todos ellos presentaban variaciones en los par\u00e1metros cin\u00e9ticos y en la distribuci\u00f3n de d\u00edmeros y tetr\u00e1meros. Estos resultados sugieren que el equilibrio entre d\u00edmeros y tetr\u00e1meros parece depender del balance entre las interacciones atractivas y repulsivas, que se establecen en la zona de interacci\u00f3n entre los d\u00edmeros.  por otro lado, la alta conservaci\u00f3n a lo largo de toda la secuencia aminoac\u00eddica permiti\u00f3 identificar hasta 292 mats en bacterias y eucariotas. Gracias a estas caracter\u00edsticas se pudo elaborar un \u00e1rbol filogen\u00e9tico en el que se resuelven los principales grupos taxon\u00f3micos, con un alto soporte estad\u00edstico en sus nodos. Adem\u00e1s, del alineamiento se observa c\u00f3mo el n\u00famero de residuos en el bucle que conecta las hojas-beta a2 y a3 sirve para distinguir claramente entre secuencias de bacterias y eucariotas. Finalmente, en vertebrados, la duplicaci\u00f3n del gen de la mat es concomitante con la aparici\u00f3n del h\u00edgado y p\u00e1ncreas. Adem\u00e1s la adaptaci\u00f3n de la secuencia de una de las copias, para proporcionar una funci\u00f3n m\u00e1s espec\u00edfica en el h\u00edgado, se ha producido gradualmente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos estructurales de la asociaci\u00f3n y evoluci\u00f3n molecular de la metionina adenosiltransferasa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos estructurales de la asociaci\u00f3n y evoluci\u00f3n molecular de la metionina adenosiltransferasa <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Perez Gabino Francisco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pajares Taranc\u00f3n M\u00aa Angeles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Gonz\u00e1lez casta\u00f1o <\/li>\n<li>\u00c1lvaro Martinez  del pozo (vocal)<\/li>\n<li>vicente Rubio zamora (vocal)<\/li>\n<li>paulino Gomez puertas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Perez Gabino Francisco En cirrosis alcog\u00f3lica y otras enfermedades hep\u00e1ticas se ha encontrado una alteraci\u00f3n en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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