{"id":69594,"date":"2018-03-09T23:14:02","date_gmt":"2018-03-09T23:14:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-gen-cyp19-aromatasa-en-osteoblastos-humanos-in-vitro-y-busqueda-de-nuevos-polimorfismos-relacionados-con-la-osteoporosis\/"},"modified":"2018-03-09T23:14:02","modified_gmt":"2018-03-09T23:14:02","slug":"estudio-de-la-expresion-del-gen-cyp19-aromatasa-en-osteoblastos-humanos-in-vitro-y-busqueda-de-nuevos-polimorfismos-relacionados-con-la-osteoporosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/estudio-de-la-expresion-del-gen-cyp19-aromatasa-en-osteoblastos-humanos-in-vitro-y-busqueda-de-nuevos-polimorfismos-relacionados-con-la-osteoporosis\/","title":{"rendered":"Estudio de la expresi\u00f3n del gen cyp19 (aromatasa) en osteoblastos humanos in vitro y b\u00fasqueda de nuevos polimorfismos relacionados con la osteoporosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana EnJuan es Guardiola <\/strong><\/h2>\n<p>La osteoporosis postmenop\u00e1usica se relaciona claramente con el d\u00e9ficit estrog\u00e9nico que se produce con la p\u00e9rdida de la funci\u00f3n ov\u00e1rica en la mujer tras la menopausia. Adem\u00e1s, en los \u00faltimos a\u00f1os, se ha observado que la bios\u00edntesis extragonadal de estr\u00f3genos ejerce una importante funci\u00f3n sobre el metabolismo \u00f3seo, tanto en mujeres postmenopa\u00fasicas como en varones. as\u00ed, la expresi\u00f3n de aromatasa por parte de las c\u00e9lulas \u00f3seas podr\u00edan determinar la concentraci\u00f3n local de estr\u00f3genos en el tejido \u00f3seo, y por lo tanto, jugar un papel muy importante tanto en la osteoporosis postmenop\u00e1usica como en la osteoporosis masculina. Por este motivo, se ha estudiado la capacidad de s\u00edntesis de estr\u00f3genos por parte del tejido \u00f3seo y su regulaci\u00f3n por distintas hormonas y citocinas. Se ha observado que los osteoblastos humanos normales in vitro expresan el gen cyp19 en condiciones no estimulantes. la dexametasona incrementa la expresi\u00f3n del gen cyp19 en osteoblastos humanos normales in vitro y la presencia de suero tiene un efecto sin\u00e9rgico sobre este efecto estimulador. En la l\u00ednea celular de osteosarcoma mg-63 la dexametasona s\u00f3lo incrementa la expresi\u00f3n del gen cyp19 en presencia de suero. La vitamina d incrementa la expresi\u00f3n del gen cyp19 en osteoblastos humanos normales in vitro y en las cuales mg-63. Esta estimulaci\u00f3n es inhibida por la presencia de fcs. La testosterona y el 17beta-estradiol incrementan la expresi\u00f3n del gen cyp19 en osteoblastos humanos normales in vitro, siendo de mayor magnitud el efecto de la testosterona. Esta estimulaci\u00f3n es inhibida por el fcs. En cambio, estos dos tratamientos no afectan la expresi\u00f3n del gen en la l\u00edna celular mg-63. La il-1beta no afecta la expresi\u00f3n del gen cyp19 en osteoblastos humanos normales in vitro ni en la l\u00ednea celular mg-63. el tnfalfa inhibe la expresi\u00f3n del gen cyp19 en osteoblastos humanos normales in vitro, tanto en ausencia como en presencia de fcs. En camb<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n del gen cyp19 (aromatasa) en osteoblastos humanos in vitro y b\u00fasqueda de nuevos polimorfismos relacionados con la osteoporosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n del gen cyp19 (aromatasa) en osteoblastos humanos in vitro y b\u00fasqueda de nuevos polimorfismos relacionados con la osteoporosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana EnJuan es Guardiola <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adolfo Diez Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Gonzalez  macias <\/li>\n<li>joan miquel Nolla sole (vocal)<\/li>\n<li>anna Messeguer navarro (vocal)<\/li>\n<li>Mar\u00eda Luisa Mari\u00f1oso barba (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana EnJuan es Guardiola La osteoporosis postmenop\u00e1usica se relaciona claramente con el d\u00e9ficit estrog\u00e9nico que se produce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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