{"id":69596,"date":"2018-03-09T23:14:06","date_gmt":"2018-03-09T23:14:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biosa%c2%adntesis-de-mediadores-lipa%c2%addicos-derivados-de-la-5-lipooxigenasa-en-el-sinusoide-hepatico-implicaciones-en-la-fibrogenesis-hepatica\/"},"modified":"2018-03-09T23:14:06","modified_gmt":"2018-03-09T23:14:06","slug":"biosa%c2%adntesis-de-mediadores-lipa%c2%addicos-derivados-de-la-5-lipooxigenasa-en-el-sinusoide-hepatico-implicaciones-en-la-fibrogenesis-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/biosa%c2%adntesis-de-mediadores-lipa%c2%addicos-derivados-de-la-5-lipooxigenasa-en-el-sinusoide-hepatico-implicaciones-en-la-fibrogenesis-hepatica\/","title":{"rendered":"Bios\u00edntesis de mediadores lip\u00eddicos derivados de la 5-lipooxigenasa en el sinusoide hep\u00e1tico. implicaciones en la fibrog\u00e9nesis hep\u00e1tica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Titos Rodr\u00edguez <\/strong><\/h2>\n<p>La fibrosis hep\u00e1tica es el resultado de un proceso inflamatorio y de reparaci\u00f3n de tejido en respuesta a un da\u00f1o hep\u00e1tico prolongado y se define como la acumulaci\u00f3n de tejido conectivo en el h\u00edgado debido a un importante desequilibrio entre la produci\u00f3n y la degradaci\u00f3n de matriz extracelular.Mientras que la fibrosis hep\u00e1tica es un proceso reversible, su estado final, la cirrosis est\u00e1 considerado como el estdio irreversible y final de la emfermedad.Cuando la cirrosis es ya severa se produce la completa desestrcturaci\u00f3n del par\u00e9nquima hepatico dando lugar a la aparici\u00f3n de insuficiencia hep\u00e1tica y trastornos hemodin\u00e1micos graves.Una de la primeras complicaciones hemodin\u00e1micas es la apari\u00f3n de hipertenci\u00f3n portal que tiene lugar como consecuencia de un incremento de la resitencia intrahep\u00e1tica al paso de flujo sangu\u00edneo portal as\u00ed como de un aumento intr\u00edseco del tono vascular de la microvasculatura hep\u00e1tica. Existe un enorme inter\u00e9s cientifico no s\u00f3lo por esclarecer los mecanismos celulares implicados en el desarrollo de fibrosis y cirrosis hep\u00e1tica sino tambi\u00e9n por identificar nuevas estrategias terap\u00e9uticas enfocadas a revertir o prevenir la prograsi\u00f3n de esta enfermedad hep\u00e1tica.  una de las posibles dianas terap\u00e9uticas la constituye la v\u00eda biosint\u00e9tica de la 5-lo. La 5-lo es la enzima clave responsable de la s\u00edntesis de lts, importantes mediadores lip\u00eddos derivados del aa.Este grupo de eicosanoides incluye al ltb4 implicado principalmente en la respuesta inflamatoria y los cisteinil-lts(ltc4\/ltd4\/lte4)que son potentes agentes vasosontrictores capaces de incrementar la permeabilidad vascular y ejercer hep\u00e1tica de perfusi\u00f3n como la extravasaci\u00f3n de fluido vascular.Adem\u00e1s , los estudios cl\u00ednicos demuestran que en los pacientes con hapatopat\u00eda existe un incremento en la producci\u00f3n de estos eicosanoides lo que se ha asociado con el desarrollo de un incremento en la resistencia intrahep\u00e1tica existe u<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bios\u00edntesis de mediadores lip\u00eddicos derivados de la 5-lipooxigenasa en el sinusoide hep\u00e1tico. implicaciones en la fibrog\u00e9nesis hep\u00e1tica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bios\u00edntesis de mediadores lip\u00eddicos derivados de la 5-lipooxigenasa en el sinusoide hep\u00e1tico. implicaciones en la fibrog\u00e9nesis hep\u00e1tica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Titos Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Claria Enrich<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lisardo Bosc\u00e1 gomar <\/li>\n<li>c\u00e9sar Picado vall\u00e9s (vocal)<\/li>\n<li>joan Gil santano (vocal)<\/li>\n<li>joan Rosello catafau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Titos Rodr\u00edguez La fibrosis hep\u00e1tica es el resultado de un proceso inflamatorio y de reparaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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