{"id":69620,"date":"2018-03-09T23:14:06","date_gmt":"2018-03-09T23:14:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-la-configuracion-absoluta-de-alcoholes-y-aminas-por-rmn-formacion-de-complejos-metalicos\/"},"modified":"2018-03-09T23:14:06","modified_gmt":"2018-03-09T23:14:06","slug":"determinacion-de-la-configuracion-absoluta-de-alcoholes-y-aminas-por-rmn-formacion-de-complejos-metalicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/determinacion-de-la-configuracion-absoluta-de-alcoholes-y-aminas-por-rmn-formacion-de-complejos-metalicos\/","title":{"rendered":"Determinaci\u00f3n de la configuraci\u00f3n absoluta de alcoholes y aminas por rmn: formaci\u00f3n de complejos met\u00e1licos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Agrelo Rosa Isabel <\/strong><\/h2>\n<p>Todos los m\u00e9todos para la determinaci\u00f3n de la configuraci\u00f3n absoluta basados en rmn, requieren la transformaci\u00f3n del sustrato quiral en dos especies que puedan ser distinguidas por espectroscop\u00eda de rmn (diasterois\u00f3meros o conf\u00f3rmes). El procedimiento requiere:  a,- derivatizaci\u00f3n del sustrato con el cda (chiral derivatizing agent).  b,- comparaci\u00f3n del espectro de rmn de 1h de las dos especies.  actualmente existen dos variantes de este m\u00e9todo:  a,- derivatizaci\u00f3n del sustrato con los dos enanti\u00f3meros del auxiliar quiral.  b,- derivatizaci\u00f3n del sustrato con un solo enanti\u00f3mero del auxiliar quiral.  el objetivo de esta tesis es el desarrollo de una metodolog\u00eda que permita la asignaci\u00f3n de la configuraci\u00f3n absoluta de compuestos org\u00e1nicos por rmn, enfocado principalmente a compuestos de origen natural con actividad biol\u00f3gica. Uno de los principales problemas que presenta el estudio de este tipo de sustratos es la disponibilidad de cantidad suficiente de muestra, de ah\u00ed que el m\u00e9todo debe contemplar una disminuci\u00f3n significativa del n\u00famero de etapas necesarias para llevar a cabo la determinaci\u00f3n de la configuraci\u00f3n.  nuestro grupo lleva a\u00f1os encaminado al desarrollo de metodolog\u00edas de trabajo que permitan reducir la cantidad de muestra necesaria para llevar a cabo estas determinaciones. Una de estas aproximaciones consiste en preparar un \u00fanico derivado del sustrato y comparar los espectors de rmn a diferentes temperaturas, que ofrece en muchos casos ventajas importantes, si bien limitadas a sustratos que no posean en sus estructuras grupos con marcado car\u00e1cter anisotr\u00f3pico (carbonilo, fenilo, etc..). Una nueva aproximaci\u00f3n, que obiviar\u00eda este tipo de dificultades y que ser\u00eda el objeto de esta tesis, consiste en la preparaci\u00f3n, otra vez, de un \u00fanico derivado seguido del registro de dos espectros de rmn, uno en condiciones normales y un segundo tras haber provocado alg\u00fan cambio conformacional en el d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de la configuraci\u00f3n absoluta de alcoholes y aminas por rmn: formaci\u00f3n de complejos met\u00e1licos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de la configuraci\u00f3n absoluta de alcoholes y aminas por rmn: formaci\u00f3n de complejos met\u00e1licos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Agrelo Rosa Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Riguera Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaqu\u00edn Rodr\u00edguez mor\u00e1n <\/li>\n<li>Antonio Herrera fern\u00e1ndez (vocal)<\/li>\n<li>tom\u00e1s Torroba p\u00e9rez (vocal)<\/li>\n<li>eva Zub\u00eda mendoza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Agrelo Rosa Isabel Todos los m\u00e9todos para la determinaci\u00f3n de la configuraci\u00f3n absoluta basados en rmn, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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