{"id":69630,"date":"2018-03-09T23:14:06","date_gmt":"2018-03-09T23:14:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-en-la-expresion-de-los-genes-involucrados-en-el-ciclo-celular-y-apoptosis-durante-el-destete-en-la-glandula-mamaria-de-rata-lactante-papel-del-gsh\/"},"modified":"2018-03-09T23:14:06","modified_gmt":"2018-03-09T23:14:06","slug":"cambios-en-la-expresion-de-los-genes-involucrados-en-el-ciclo-celular-y-apoptosis-durante-el-destete-en-la-glandula-mamaria-de-rata-lactante-papel-del-gsh","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-en-la-expresion-de-los-genes-involucrados-en-el-ciclo-celular-y-apoptosis-durante-el-destete-en-la-glandula-mamaria-de-rata-lactante-papel-del-gsh\/","title":{"rendered":"Cambios en la expresi\u00f3n de los genes involucrados en el ciclo celular y apoptosis durante el destete en la gl\u00e1ndula mamaria de rata lactante. papel del gsh."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Zaragoz\u00e1 Colom <\/strong><\/h2>\n<p>En la gl\u00e1ndula mamaria, al final de la lactancia, o al separar las cr\u00edas de la madre, la acumulaci\u00f3n de leche y el descenso en los niveles de hormonas lactog\u00e9nicas (glucocorticoides, insulina y prolactina) inician una cascada de se\u00f1alizaci\u00f3n intracelular que conduce a la muerte de las c\u00e9lulas epiteliales secretoras por apoptosis y a la regresi\u00f3n de tejido mamario. Estas caracter\u00edsticas tan particulares hacen de este tejido un excelente modelo d\u00f3nde estudiar la funci\u00f3n y regulaci\u00f3n de todos aquellos genes implicados en la apoptosis.  en la gl\u00e1ndula mamaria de rata lactante, el destete produce apoptosis de las c\u00e9lulas epiteliales, un proceso caracterizado por la liberaci\u00f3n de citocromo c mitocondrial al citosol. Esta prote\u00edna, a su vez, desencadena la activaci\u00f3n de toda una cascada de caspasas, responsables de los cambios observados en la muerte celular programada. Uno de estos cambios, caracter\u00edsticos de la apoptosis es la fragmentaci\u00f3n del adn internucleosomal, por activaci\u00f3n de una endonucleasa dependiente de caspasas. Si realizamos una electroforesis de adn a las 8 horas de destete ya se observa un patr\u00f3n en escalera t\u00edpico de la fragmentaci\u00f3n del mismo. Adem\u00e1s de estos cambios caracter\u00edsticos del proceso apopt\u00f3tico, tambi\u00e9n se observan una serie de cambios a nivel gen\u00e9tico: el destete de 2 horas produce una inducci\u00f3n temprana de p53, mientras que otros genes como c-jun o jnk no aumentan hasta 8 o 24 horas de destete. La expresi\u00f3n y los niveles de prote\u00edna de p21cip1 y p27kip1, ambos inhibidores de las quinasas dependientes de ciclinas y por ello favorecen la detenci\u00f3n del ciclo celular, est\u00e1 significativamente aumentada tras el destete si comparamos con ratas control en el pico de la lactancia.  todos los cambios anteriormente mencionados tambi\u00e9n tienen lugar en la gl\u00e1ndula mamaria cuando se inhibe la transulfuraci\u00f3n hep\u00e1tica tras un tratamiento con ppg durante tres d\u00edas. Este efecto se ve parcia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios en la expresi\u00f3n de los genes involucrados en el ciclo celular y apoptosis durante el destete en la gl\u00e1ndula mamaria de rata lactante. papel del gsh.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios en la expresi\u00f3n de los genes involucrados en el ciclo celular y apoptosis durante el destete en la gl\u00e1ndula mamaria de rata lactante. papel del gsh. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Zaragoz\u00e1 Colom <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Vi\u00f1as Ribes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Franco vera <\/li>\n<li>Antonio Llombart bosch (vocal)<\/li>\n<li>llu\u00eds Arola ferrer (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Medina jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Zaragoz\u00e1 Colom En la gl\u00e1ndula mamaria, al final de la lactancia, o al separar las cr\u00edas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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