{"id":69642,"date":"2018-03-09T23:14:06","date_gmt":"2018-03-09T23:14:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-antiproliferativa-de-resveratrol-frente-al-desarrollo-de-cancer-de-glandula-mamaria\/"},"modified":"2018-03-09T23:14:06","modified_gmt":"2018-03-09T23:14:06","slug":"actividad-antiproliferativa-de-resveratrol-frente-al-desarrollo-de-cancer-de-glandula-mamaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/extremadura\/actividad-antiproliferativa-de-resveratrol-frente-al-desarrollo-de-cancer-de-glandula-mamaria\/","title":{"rendered":"Actividad antiproliferativa de resveratrol frente al desarrollo de c\u00e1ncer de gl\u00e1ndula mamaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eulacia Pozo Guisado <\/strong><\/h2>\n<p>El resveratrol es un fitoalexina que se encuentra en cantidades significativas en la uva y en el vino tinto. Diferentes estudios han mostrado que le resveratrol presenta efectos beneficiosos frente a enfermedades cardiovasculares y frente al desarrollo del c\u00e1ncer.  en este estudio hemos observado que el resveratrol inhibe la proliferaci\u00f3n celular de las l\u00edneas tumorales de peitleio de gl\u00e1ndula mamaria humana  mcf-7, que son positivas para el receptor de estr\u00f3genos alfa (eralfa), y mda-mb-231, que carece de dicho receptor. este efecto antiprolfierativo est\u00e1 relacionado con la inducci\u00f3n de muerte celular apopt\u00f3tica en las primeras y no apot\u00f3tica en las segundas. el resveratrol, cuya estructura qu\u00edmica es similar a la de ciertos estr\u00f3genos sint\u00e9ticos, se une al receptor de estr\u00f3genos alfa (eralfa) y modula su actividad.  el eralfa, adem\u00e1s de su funci\u00f3n como regulador transcripcional, interacciona con pi3k, contribuyendo al control de rutas de se\u00f1alizaci\u00f3n implicadas en supervivencia, proliferaci\u00f3n y apoptosis. Hemos observado que resveratrol modula la actividad pi3k dependiente del eralfa  en c\u00e9lulas de c\u00e1ncer de mama humana mcf-7, ejerciendo un efecto agonista sobre este receptor a concentraciones bajas y un efecto antagonista a concentraciones elevadas. El efecto de resveratrol sobre la actividad pi3k asociada al eralfa, que tiene lugar a concentraciones a las que induce apoptosis, es transducida hasta otros componentes de la ruta como pkb\/akt, gsk-3, ciclina d1 y beta-catenina. la apoptosis inducida por resveratrol en las c\u00e9lulas mcf-7, est\u00e1 relacionada con cambios en rutas de supervivencia como la de nf-kb, la cual est\u00e1 a su vez regulada pro la v\u00eda de pi3k. De este modo, resveratrol induce apoptosis disminuyendo los niveles de la prote\u00edna antiapopt\u00f3tica bcl-2. Este mecanismo de apoptosis es independiente de la liberaci\u00f3n de citocromo c, de la activaci\u00f3n de caspasas, de la proteolisis de la parp y de la fragmentaci\u00f3n del dna. Estos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad antiproliferativa de resveratrol frente al desarrollo de c\u00e1ncer de gl\u00e1ndula mamaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad antiproliferativa de resveratrol frente al desarrollo de c\u00e1ncer de gl\u00e1ndula mamaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eulacia Pozo Guisado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Fern\u00e1ndez Salguero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: abelardo L\u00f3pez rivas <\/li>\n<li>Alberto Alvarez barrientos (vocal)<\/li>\n<li>Mar\u00eda  isabel Fabregat romero (vocal)<\/li>\n<li>Jaime Merino fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eulacia Pozo Guisado El resveratrol es un fitoalexina que se encuentra en cantidades significativas en la uva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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