{"id":69698,"date":"2018-03-09T23:14:09","date_gmt":"2018-03-09T23:14:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-factores-geneticos-y-epidemiologicos-en-la-enfermedad-de-parkinson-y-en-parkinsonismos-inducidos-por-farmacos\/"},"modified":"2018-03-09T23:14:09","modified_gmt":"2018-03-09T23:14:09","slug":"estudio-de-factores-geneticos-y-epidemiologicos-en-la-enfermedad-de-parkinson-y-en-parkinsonismos-inducidos-por-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/estudio-de-factores-geneticos-y-epidemiologicos-en-la-enfermedad-de-parkinson-y-en-parkinsonismos-inducidos-por-farmacos\/","title":{"rendered":"Estudio de factores geneticos  y epidemiologicos  en la enfermedad de parkinson y en parkinsonismos inducidos por farmacos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Blazquez Estrada <\/strong><\/h2>\n<p>La etiolog\u00eda de la enfermedad de parkinson (ep) y otros parkinsonismos contin\u00faa siendo desconocida hoy en d\u00eda. Durante la \u00faltima d\u00e9cada se han estudiado factores gen\u00e9ticos y ambientales relacionados con su aparici\u00f3n. est\u00e1n descritas mutaciones en varios genes y locus, causantes de ep familiar y espor\u00e1dica de inicio precoz. El consumo de tabaco y caf\u00e9 est\u00e1 asociado con una menor preValencia de ep. Por el contrario la exposici\u00f3n a neurotoxinas como mptp, pesticidas y herbicidas aumenta el riesgo de padecerla.  en el h\u00edgado, que es el principal \u00f3rgano detoxificador , se encuentran dos grandes familias de enzimas (fase i y ii) que desempe\u00f1an funciones en el metabolismo de compuestos xenobi\u00f3ticos, f\u00e1rmacos, metabolitos intermediarios y dopamina. La susceptibilidad a dichas neurotoxinas as\u00ed como a determinados f\u00e1rmacos que pueden inducir parkinsonismo (pif), puede estar determinada por polimorfismos gen\u00e9ticos que afecten a la expresi\u00f3n o actividad de las correspondientes enzimas.  dada la ausencia de estudios gen\u00e9ticos y epidemiol\u00f3gicos en la ep y pif en nuestro medio, nos planteamos la realizaci\u00f3n de un estudio caso-control en el \u00e1rea del hospital universitario de salamanca, con los siguientes objetivos: determinar la existencia de factores ambientales que predispongan al desarrollo de ep, analizar la distribuci\u00f3n de los alelos y genotipos de los genes cyp2d6, gstm1, gstt1, gstp1 y apo e, y estudiar la existencia de mutaciones en los casos de ep familiar.  en nuestra muestra, adem\u00e1s de la edad, la existencia de antecedentes familiares constituye un factor de riesgo, el tabaco y el caf\u00e9 desempe\u00f1an un papel protector y la exposici\u00f3n laboral a pesticidas predispone al desarrollo de parkinsonismo. No existen diferencias en la distribuci\u00f3n de alelos y genotipos en los genes estudiados. Se detectaron dos nuevas mutaciones en el gen park2 en cinco pacientes pertenecientes a dos familias con ep de inicio precoz, no des<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de factores geneticos  y epidemiologicos  en la enfermedad de parkinson y en parkinsonismos inducidos por farmacos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de factores geneticos  y epidemiologicos  en la enfermedad de parkinson y en parkinsonismos inducidos por farmacos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Blazquez Estrada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Fermoso Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Sanchez rodriguez <\/li>\n<li>Jos\u00e9 felix Marti masso (vocal)<\/li>\n<li>angel Noya garcia (vocal)<\/li>\n<li>Jos\u00e9 angel Berciano blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Blazquez Estrada La etiolog\u00eda de la enfermedad de parkinson (ep) y otros parkinsonismos contin\u00faa siendo desconocida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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